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• W3012352782 abstract "A key characteristic of Alzheimer's disease (AD) is loss of episodic memory-memory for what happened, where and when; this final aspect-timing-is the focus of the present article. Although timing deficits have been reported in AD patients, few parallel studies have been performed in animals, compromising the translational potential of these findings. We looked for timing impairments in the APPswe/PS1dE9 mouse model of AD at 4-5 months of age, before significant plaques have developed. In Experiments 1 and 2a mice were trained with auditory stimuli that were followed by food, either immediately (delay stimulus; Experiments 1 and 2a) or after a short interval (trace stimulus; Experiment 1). In Experiment 1 APPswe/PS1dEdE9 mice conditioned normally, but showed more variable timing of the delay-conditioned cue. Experiment 2 examined timing of two delay-conditioned CSs, with Experiment 2a using mice 4-5 months old, and Experiment 2b mice at 6-8 months. With the longer conditional stimulus (CS) the transgenic mice showed both more variable timing and earlier timed peak responding than wild-type mice; these effects were not influenced by age. Our results bear similarity to those seen in AD patients, raising the possibility that they have diagnostic potential. They also resemble deficits in animals with dorsal hippocampal lesions, suggesting that they could be mediated by this area. Activated microglia, a component of the immune response thought to be driven by the elevated levels of β-amyloid, were elevated in both dentate gyrus and striatum of young transgenic mice, providing some support for this proposal. (PsycINFO Database Record (c) 2020 APA, all rights reserved)." @default.
• W3012352782 created "2020-03-23" @default.
• W3012352782 creator A5015805264 @default.
• W3012352782 creator A5037540892 @default.
• W3012352782 creator A5088397516 @default.
• W3012352782 date "2020-04-01" @default.
• W3012352782 modified "2023-09-24" @default.
• W3012352782 title "Timing impairments in early Alzheimer’s disease: Evidence from a mouse model." @default.
• W3012352782 cites W1480602442 @default.
• W3012352782 cites W1556362327 @default.
• W3012352782 cites W1608105618 @default.
• W3012352782 cites W1965545113 @default.
• W3012352782 cites W1966014719 @default.
• W3012352782 cites W1967297891 @default.
• W3012352782 cites W1967375871 @default.
• W3012352782 cites W1967823816 @default.
• W3012352782 cites W1969803066 @default.
• W3012352782 cites W1969846896 @default.
• W3012352782 cites W1971210753 @default.
• W3012352782 cites W1972438875 @default.
• W3012352782 cites W1972571098 @default.
• W3012352782 cites W1975895756 @default.
• W3012352782 cites W1977002082 @default.
• W3012352782 cites W1978107420 @default.
• W3012352782 cites W1980698104 @default.
• W3012352782 cites W1981891948 @default.
• W3012352782 cites W1982313782 @default.
• W3012352782 cites W1983850663 @default.
• W3012352782 cites W1989186580 @default.
• W3012352782 cites W1990588924 @default.
• W3012352782 cites W1994087800 @default.
• W3012352782 cites W1997170399 @default.
• W3012352782 cites W2000664790 @default.
• W3012352782 cites W2005547013 @default.
• W3012352782 cites W2005719973 @default.
• W3012352782 cites W2007705951 @default.
• W3012352782 cites W2009282373 @default.
• W3012352782 cites W2015353573 @default.
• W3012352782 cites W2016172877 @default.
• W3012352782 cites W2027201680 @default.
• W3012352782 cites W2028660906 @default.
• W3012352782 cites W2036150705 @default.
• W3012352782 cites W2040375196 @default.
• W3012352782 cites W2041572758 @default.
• W3012352782 cites W2044871756 @default.
• W3012352782 cites W2047999252 @default.
• W3012352782 cites W2049512449 @default.
• W3012352782 cites W2050633656 @default.
• W3012352782 cites W2050926782 @default.
• W3012352782 cites W2051211720 @default.
• W3012352782 cites W2053016988 @default.
• W3012352782 cites W2057552703 @default.
• W3012352782 cites W2059212904 @default.
• W3012352782 cites W2060927124 @default.
• W3012352782 cites W2062351166 @default.
• W3012352782 cites W2063236931 @default.
• W3012352782 cites W2068260975 @default.
• W3012352782 cites W2075348467 @default.
• W3012352782 cites W2076531205 @default.
• W3012352782 cites W2079206376 @default.
• W3012352782 cites W2082446434 @default.
• W3012352782 cites W2083317764 @default.
• W3012352782 cites W2084762017 @default.
• W3012352782 cites W2085435800 @default.
• W3012352782 cites W2090811490 @default.
• W3012352782 cites W2092257137 @default.
• W3012352782 cites W2105203252 @default.
• W3012352782 cites W2111191371 @default.
• W3012352782 cites W2112880587 @default.
• W3012352782 cites W2114984406 @default.
• W3012352782 cites W2115271248 @default.
• W3012352782 cites W2116572744 @default.
• W3012352782 cites W2123993733 @default.
• W3012352782 cites W2124190705 @default.
• W3012352782 cites W2127540128 @default.
• W3012352782 cites W2131171370 @default.
• W3012352782 cites W2136898335 @default.
• W3012352782 cites W2137319779 @default.
• W3012352782 cites W2138140089 @default.
• W3012352782 cites W2138699752 @default.
• W3012352782 cites W2138878035 @default.
• W3012352782 cites W2140928605 @default.
• W3012352782 cites W2141644343 @default.
• W3012352782 cites W2143944537 @default.
• W3012352782 cites W2151236915 @default.
• W3012352782 cites W2156275187 @default.
• W3012352782 cites W2159879468 @default.
• W3012352782 cites W2163301650 @default.
• W3012352782 cites W2164789388 @default.
• W3012352782 cites W2167703395 @default.
• W3012352782 cites W2169152986 @default.
• W3012352782 cites W2169195417 @default.
• W3012352782 cites W221859048 @default.
• W3012352782 cites W2261085470 @default.
• W3012352782 cites W2274088279 @default.
• W3012352782 cites W2288292510 @default.
• W3012352782 cites W2461584436 @default.
• W3012352782 cites W2533905828 @default.

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