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• W3012387611 abstract "Beta-cell-specific transgenic mice provide an invaluable model for dissecting the direct signaling mechanisms involved in regulating beta-cell structure and function. Furthermore, generating novel transgenic models is now easier and more cost-effective than ever, thanks to exciting novel approaches such as CRISPR. Here, we describe the commonly used approaches for generating and maintaining beta-cell-specific transgenic models and some of the considerations involved in their use. This includes the use of different beta-cell-specific promoters (e.g., pancreatic and duodenal homeobox factor 1 (Pdx1), rat insulin 2 promoter (RIP), and mouse insulin 1 promoter (MIP)) to drive site-specific recombinase technology. Important considerations during selection include level and uniformity of expression in the beta-cell population, ectopic transgene expression, and the use of inducible models. This chapter provides a guide to the procurement, generation, and maintenance of a beta-cell-specific transgene colony from preexisting Cre and loxP mouse strains, providing methods for crossbreeding and genotyping, as well as subsequent maintenance and, in the case of inducible models, transgenic induction." @default.
• W3012387611 created "2020-03-23" @default.
• W3012387611 creator A5003911277 @default.
• W3012387611 creator A5010122556 @default.
• W3012387611 creator A5053402884 @default.
• W3012387611 date "2020-01-01" @default.
• W3012387611 modified "2023-09-30" @default.
• W3012387611 title "Generating Beta-Cell-Specific Transgenic Mice Using the Cre-Lox System" @default.
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• W3012387611 doi "https://doi.org/10.1007/978-1-0716-0385-7_13" @default.
• W3012387611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32180194" @default.
• W3012387611 hasPublicationYear "2020" @default.
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