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• W3012487130 abstract "Platelet-activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose-dependently induced, whilst lyso-PAF (PAF precursor) showed no effect on acrosome reaction of capacitated human spermatozoa. Treatment with PAF for 90 min enhanced tyrosine phosphorylation and expression of extracellular signal-regulated protein kinases (ERK) 1 and 2 in human spermatozoa. Moreover, pre-treatment with the ERK inhibitor U0126 significantly and dose-dependently suppressed PAF-induced acrosome reaction. Therefore, PAF may be actively involved in the modulation of sperm acrosome reaction by interacting with ERK. The role of PAF in fertilisation warrants further investigation." @default.
• W3012487130 created "2020-03-23" @default.
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• W3012487130 date "2020-03-18" @default.
• W3012487130 modified "2023-10-02" @default.
• W3012487130 title "Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa" @default.
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• W3012487130 doi "https://doi.org/10.1111/and.13565" @default.
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