Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012487983> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3012487983 abstract "7060 Background: Malignant cells from different cancers express different profiles of chemokine receptors (CKR). Their presence may influence site-specific spread of tumor cells, by enabling them to respond to chemokine gradient, and may increase cell sensibility to chemokine mediated proliferative and anti-apoptotic stimuli. Notch ability to positively regulate CKR has been reported: stimulation of Pax5-/- pre-B cells with the Notch ligand Delta-1 results in induction of transcripts for CCR4, CCR8 and CXCR 6; the Delta-1-dependent regulation of Langerhans cell development includes induction of CCR6 expression resulting in the activation of chemotactic response to MIP-1a; Notch controls CCR7 signaling a regulator of CNS infiltration in T-acute lymphoblastic leukemia (T-ALL). Methods: This work aims to explore the correlation between the activation of the Notch oncogenic pathway in T-ALL and multiple myeloma (MM) cells and the aberrant expression CKR. Human T-ALL cell lines were treated with the Notch activation inhibitor, DAPT, or with a potent inhibitor of the Notch target, C-MYC, and evaluated the expression and functions of CCR9, CCR5, and CXCR4. Results: Treatment of human T-ALL and MM cell lines with pharmacologic inhibitors of Notch receptor activation produced a significant reduction of CCR9, CCR5 and CXCR4 expression, at both mRNA and protein levels. Results were confirmed by chemotaxis and survival assays. We identified the product of C-MYC gene as a possible mediator of Notch effect in regulating CKR networks in T-ALL and MM. Conclusions: These results suggest that Notch receptors play a previously unknown role in cancer progression and metastasis, by maintaining the expression levels of CKR. In conclusion, the identification of the potential axis Notch/CKR could have a prognostic value and provide the rationale for a tailored approach, since both Notch and CKR are targeted by emerging drugs." @default.
- W3012487983 created "2020-03-23" @default.
- W3012487983 creator A5002719347 @default.
- W3012487983 creator A5009063659 @default.
- W3012487983 creator A5016954236 @default.
- W3012487983 creator A5022084686 @default.
- W3012487983 creator A5026785778 @default.
- W3012487983 creator A5038481242 @default.
- W3012487983 creator A5043523278 @default.
- W3012487983 creator A5052000070 @default.
- W3012487983 creator A5052327666 @default.
- W3012487983 creator A5052437060 @default.
- W3012487983 creator A5055996591 @default.
- W3012487983 creator A5062719384 @default.
- W3012487983 creator A5068576376 @default.
- W3012487983 creator A5076729497 @default.
- W3012487983 creator A5077243530 @default.
- W3012487983 creator A5079497490 @default.
- W3012487983 creator A5089312555 @default.
- W3012487983 date "2013-05-20" @default.
- W3012487983 modified "2023-09-26" @default.
- W3012487983 title "Chemokine receptors as novel targets of the oncogene Notch1 in acute lymphoblastic leukemia." @default.
- W3012487983 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.7060" @default.
- W3012487983 hasPublicationYear "2013" @default.
- W3012487983 type Work @default.
- W3012487983 sameAs 3012487983 @default.
- W3012487983 citedByCount "0" @default.
- W3012487983 crossrefType "journal-article" @default.
- W3012487983 hasAuthorship W3012487983A5002719347 @default.
- W3012487983 hasAuthorship W3012487983A5009063659 @default.
- W3012487983 hasAuthorship W3012487983A5016954236 @default.
- W3012487983 hasAuthorship W3012487983A5022084686 @default.
- W3012487983 hasAuthorship W3012487983A5026785778 @default.
- W3012487983 hasAuthorship W3012487983A5038481242 @default.
- W3012487983 hasAuthorship W3012487983A5043523278 @default.
- W3012487983 hasAuthorship W3012487983A5052000070 @default.
- W3012487983 hasAuthorship W3012487983A5052327666 @default.
- W3012487983 hasAuthorship W3012487983A5052437060 @default.
- W3012487983 hasAuthorship W3012487983A5055996591 @default.
- W3012487983 hasAuthorship W3012487983A5062719384 @default.
- W3012487983 hasAuthorship W3012487983A5068576376 @default.
- W3012487983 hasAuthorship W3012487983A5076729497 @default.
- W3012487983 hasAuthorship W3012487983A5077243530 @default.
- W3012487983 hasAuthorship W3012487983A5079497490 @default.
- W3012487983 hasAuthorship W3012487983A5089312555 @default.
- W3012487983 hasConcept C121608353 @default.
- W3012487983 hasConcept C126322002 @default.
- W3012487983 hasConcept C12823836 @default.
- W3012487983 hasConcept C13373296 @default.
- W3012487983 hasConcept C170493617 @default.
- W3012487983 hasConcept C203014093 @default.
- W3012487983 hasConcept C2778461978 @default.
- W3012487983 hasConcept C2781018059 @default.
- W3012487983 hasConcept C2909962599 @default.
- W3012487983 hasConcept C29537977 @default.
- W3012487983 hasConcept C502942594 @default.
- W3012487983 hasConcept C71924100 @default.
- W3012487983 hasConceptScore W3012487983C121608353 @default.
- W3012487983 hasConceptScore W3012487983C126322002 @default.
- W3012487983 hasConceptScore W3012487983C12823836 @default.
- W3012487983 hasConceptScore W3012487983C13373296 @default.
- W3012487983 hasConceptScore W3012487983C170493617 @default.
- W3012487983 hasConceptScore W3012487983C203014093 @default.
- W3012487983 hasConceptScore W3012487983C2778461978 @default.
- W3012487983 hasConceptScore W3012487983C2781018059 @default.
- W3012487983 hasConceptScore W3012487983C2909962599 @default.
- W3012487983 hasConceptScore W3012487983C29537977 @default.
- W3012487983 hasConceptScore W3012487983C502942594 @default.
- W3012487983 hasConceptScore W3012487983C71924100 @default.
- W3012487983 hasLocation W30124879831 @default.
- W3012487983 hasOpenAccess W3012487983 @default.
- W3012487983 hasPrimaryLocation W30124879831 @default.
- W3012487983 hasRelatedWork W1554883520 @default.
- W3012487983 hasRelatedWork W1965387394 @default.
- W3012487983 hasRelatedWork W2007240193 @default.
- W3012487983 hasRelatedWork W2008690332 @default.
- W3012487983 hasRelatedWork W2015486137 @default.
- W3012487983 hasRelatedWork W2016703157 @default.
- W3012487983 hasRelatedWork W2021230504 @default.
- W3012487983 hasRelatedWork W2040483936 @default.
- W3012487983 hasRelatedWork W2144693713 @default.
- W3012487983 hasRelatedWork W2201595168 @default.
- W3012487983 hasRelatedWork W2342789489 @default.
- W3012487983 hasRelatedWork W2417787511 @default.
- W3012487983 hasRelatedWork W2476041726 @default.
- W3012487983 hasRelatedWork W2597022636 @default.
- W3012487983 hasRelatedWork W2620161165 @default.
- W3012487983 hasRelatedWork W2883791796 @default.
- W3012487983 hasRelatedWork W2900459894 @default.
- W3012487983 hasRelatedWork W2901967746 @default.
- W3012487983 hasRelatedWork W3007389312 @default.
- W3012487983 hasRelatedWork W3108862937 @default.
- W3012487983 isParatext "false" @default.
- W3012487983 isRetracted "false" @default.
- W3012487983 magId "3012487983" @default.
- W3012487983 workType "article" @default.