Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012489957> ?p ?o ?g. }
- W3012489957 abstract "The embryos of Nelumbo nucifera Gaertn seeds, lianzixin, are used in China as food and traditional herbal medicine. Principal therapeutic indications are insomnia, anxiety and pyrexia. Caffeine is a psychostimulant and excessive use predisposes to cell damage and neurotoxicity. We aimed to investigate the potential protect effect of Neferine and lianzixin extracts on undifferentiated caffeine-damaged phaeochromocytoma cells (PC12 cells).A cell damage model based on undifferentiated PC12 was established with caffeine. Effect of Lianzixin extracts (total alkaloids, alcohol extract and water extract) and neferine on caffeine-damaged PC12 cells was evaluated. Cell viability was assessed using the methyl thiazolyl tetrazolium (MTT) assay, cellular morphology by inverted microscope, the nucleus by Hoechst 33342 staining and cleaved poly ADP-ribose polymerase (PARP) expression by western blot analysis.Lianzixin extracts (total alkaloids, alcohol extract and water extract) and neferine improved the viability of PC12 cells damaged by caffeine. The morphology of PC12 cells pretreated with neferine, or alcohol or water extract of lianzixin aggregated and attached better than caffeine-damaged cells, but cells pretreated with total alkaloids of lianzixin showed abnormal morphology. Compared with caffeine-damaged cells, cells pretreated with neferine, or alcohol or water extract of lianzixin showed a notable increase in nucleus staining and an obvious decrease in cleaved PARP expression.Lianzixin extracts and neferine have protective effects against caffeine-induced damage in PC12 cells, which laid a foundation for finding a new medicine value of Lianzixin." @default.
- W3012489957 created "2020-03-23" @default.
- W3012489957 creator A5023354420 @default.
- W3012489957 creator A5029747601 @default.
- W3012489957 creator A5034535783 @default.
- W3012489957 creator A5048826252 @default.
- W3012489957 creator A5058473496 @default.
- W3012489957 creator A5079985761 @default.
- W3012489957 date "2020-03-06" @default.
- W3012489957 modified "2023-10-06" @default.
- W3012489957 title "Neferine and lianzixin extracts have protective effects on undifferentiated caffeine-damaged PC12 cells" @default.
- W3012489957 cites W1877991748 @default.
- W3012489957 cites W1982244904 @default.
- W3012489957 cites W2004249391 @default.
- W3012489957 cites W2010185022 @default.
- W3012489957 cites W2013914182 @default.
- W3012489957 cites W2016108754 @default.
- W3012489957 cites W2025236490 @default.
- W3012489957 cites W2026994377 @default.
- W3012489957 cites W2037698682 @default.
- W3012489957 cites W2041626049 @default.
- W3012489957 cites W2042751501 @default.
- W3012489957 cites W2046263408 @default.
- W3012489957 cites W2055042723 @default.
- W3012489957 cites W2055634483 @default.
- W3012489957 cites W2062274041 @default.
- W3012489957 cites W2063035156 @default.
- W3012489957 cites W2063933234 @default.
- W3012489957 cites W2064199204 @default.
- W3012489957 cites W2071899832 @default.
- W3012489957 cites W2082625505 @default.
- W3012489957 cites W2084074773 @default.
- W3012489957 cites W2084313036 @default.
- W3012489957 cites W2088511159 @default.
- W3012489957 cites W2089043139 @default.
- W3012489957 cites W2107223520 @default.
- W3012489957 cites W2107342116 @default.
- W3012489957 cites W2131776091 @default.
- W3012489957 cites W2136717001 @default.
- W3012489957 cites W2155240101 @default.
- W3012489957 cites W2159443200 @default.
- W3012489957 cites W2170788312 @default.
- W3012489957 cites W2181410714 @default.
- W3012489957 cites W2218290242 @default.
- W3012489957 cites W2257643528 @default.
- W3012489957 cites W2314874570 @default.
- W3012489957 cites W23640957 @default.
- W3012489957 cites W2393805863 @default.
- W3012489957 cites W2480130713 @default.
- W3012489957 cites W2525023887 @default.
- W3012489957 cites W2582077019 @default.
- W3012489957 cites W2582463690 @default.
- W3012489957 cites W2596856023 @default.
- W3012489957 cites W2760861770 @default.
- W3012489957 cites W2767840752 @default.
- W3012489957 cites W4253100484 @default.
- W3012489957 doi "https://doi.org/10.1186/s12906-020-2872-2" @default.
- W3012489957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7076826" @default.
- W3012489957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32143612" @default.
- W3012489957 hasPublicationYear "2020" @default.
- W3012489957 type Work @default.
- W3012489957 sameAs 3012489957 @default.
- W3012489957 citedByCount "7" @default.
- W3012489957 countsByYear W30124899572021 @default.
- W3012489957 countsByYear W30124899572022 @default.
- W3012489957 countsByYear W30124899572023 @default.
- W3012489957 crossrefType "journal-article" @default.
- W3012489957 hasAuthorship W3012489957A5023354420 @default.
- W3012489957 hasAuthorship W3012489957A5029747601 @default.
- W3012489957 hasAuthorship W3012489957A5034535783 @default.
- W3012489957 hasAuthorship W3012489957A5048826252 @default.
- W3012489957 hasAuthorship W3012489957A5058473496 @default.
- W3012489957 hasAuthorship W3012489957A5079985761 @default.
- W3012489957 hasBestOaLocation W30124899571 @default.
- W3012489957 hasConcept C134018914 @default.
- W3012489957 hasConcept C1491633281 @default.
- W3012489957 hasConcept C181199279 @default.
- W3012489957 hasConcept C182979987 @default.
- W3012489957 hasConcept C185592680 @default.
- W3012489957 hasConcept C2778500429 @default.
- W3012489957 hasConcept C53227056 @default.
- W3012489957 hasConcept C54355233 @default.
- W3012489957 hasConcept C55493867 @default.
- W3012489957 hasConcept C556039675 @default.
- W3012489957 hasConcept C71924100 @default.
- W3012489957 hasConcept C74864618 @default.
- W3012489957 hasConcept C82381507 @default.
- W3012489957 hasConcept C86803240 @default.
- W3012489957 hasConcept C98274493 @default.
- W3012489957 hasConceptScore W3012489957C134018914 @default.
- W3012489957 hasConceptScore W3012489957C1491633281 @default.
- W3012489957 hasConceptScore W3012489957C181199279 @default.
- W3012489957 hasConceptScore W3012489957C182979987 @default.
- W3012489957 hasConceptScore W3012489957C185592680 @default.
- W3012489957 hasConceptScore W3012489957C2778500429 @default.
- W3012489957 hasConceptScore W3012489957C53227056 @default.
- W3012489957 hasConceptScore W3012489957C54355233 @default.
- W3012489957 hasConceptScore W3012489957C55493867 @default.
- W3012489957 hasConceptScore W3012489957C556039675 @default.
- W3012489957 hasConceptScore W3012489957C71924100 @default.