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• W3012495265 endingPage "116778" @default.
• W3012495265 startingPage "116778" @default.
• W3012495265 abstract "Abstract N-methyl- d -aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide, are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of these compounds are also drugs of abuse. Intravenous ketamine, a dissociative anesthetic that induces complex downstream effects via NMDARs, rapidly reduces depressive and suicidal symptoms in treatment-resistant depression (TRD), as demonstrated by several trials. Recently, the United States Food and Drug Administration (FDA) approved an intranasal version of ketamine (esketamine) for TRD. The United States Drug Enforcement Agency (DEA) lists ketamine as a Class III scheduled drug (moderate-low potential for physical and psychological abuse). The FDA has established a Risk Evaluation and Management Strategy (REMS) program to ensure proper drug storage, handling, dispensing, and monitoring intranasal esketamine to minimize misuse/abuse opportunities. Nitrous Oxide is a colorless, odorless, gas that has been in medical use for over 150 years. The mechanisms of action of nitrous oxide are not fully understood; however, it is known to act as a non-competitive inhibitor of NMDA-type glutamate receptors. Currently, nitrous oxide is used for inhalational general anesthesia and analgesia for short procedures. Inhaled nitrous oxide is also used recreationally, primarily by teens and young adults, but is not believed to have strong addiction potential. In contrast to ketamine, nitrous oxide is not a controlled substance and can be legally purchased without a prescription. A recent double-blind, prospective, cross-over study demonstrated that nitrous oxide reduced depressive symptoms in a group of severely ill TRD patients. Though this is a promising initial study, further investigation is needed." @default.
• W3012495265 created "2020-03-23" @default.
• W3012495265 creator A5011090328 @default.
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• W3012495265 creator A5089851639 @default.
• W3012495265 date "2020-05-01" @default.
• W3012495265 modified "2023-10-17" @default.
• W3012495265 title "Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents" @default.
• W3012495265 cites W1486861613 @default.
• W3012495265 cites W1548847874 @default.
• W3012495265 cites W1618080288 @default.
• W3012495265 cites W1756664299 @default.
• W3012495265 cites W1969644317 @default.
• W3012495265 cites W1970624920 @default.
• W3012495265 cites W1973767115 @default.
• W3012495265 cites W1976396510 @default.
• W3012495265 cites W1984373319 @default.
• W3012495265 cites W1989163516 @default.
• W3012495265 cites W1991158321 @default.
• W3012495265 cites W1992799081 @default.
• W3012495265 cites W1996780673 @default.
• W3012495265 cites W2000534870 @default.
• W3012495265 cites W2002580140 @default.
• W3012495265 cites W2013310286 @default.
• W3012495265 cites W2020235530 @default.
• W3012495265 cites W2023081218 @default.
• W3012495265 cites W2025543055 @default.
• W3012495265 cites W2028682826 @default.
• W3012495265 cites W2028884770 @default.
• W3012495265 cites W2036377942 @default.
• W3012495265 cites W2040381473 @default.
• W3012495265 cites W2050983079 @default.
• W3012495265 cites W2052665050 @default.
• W3012495265 cites W2059322546 @default.
• W3012495265 cites W2066619230 @default.
• W3012495265 cites W2067718897 @default.
• W3012495265 cites W2069039025 @default.
• W3012495265 cites W2069732451 @default.
• W3012495265 cites W2072800634 @default.
• W3012495265 cites W2083217606 @default.
• W3012495265 cites W2085495971 @default.
• W3012495265 cites W2086305648 @default.
• W3012495265 cites W2091363925 @default.
• W3012495265 cites W2096075219 @default.
• W3012495265 cites W2103255996 @default.
• W3012495265 cites W2108403304 @default.
• W3012495265 cites W2109334244 @default.
• W3012495265 cites W2122328323 @default.
• W3012495265 cites W2123488676 @default.
• W3012495265 cites W2124131808 @default.
• W3012495265 cites W2126956784 @default.
• W3012495265 cites W2128918664 @default.
• W3012495265 cites W2131619687 @default.
• W3012495265 cites W2132324173 @default.
• W3012495265 cites W2135295743 @default.
• W3012495265 cites W2146170141 @default.
• W3012495265 cites W2157040702 @default.
• W3012495265 cites W2159804446 @default.
• W3012495265 cites W2206305343 @default.
• W3012495265 cites W2289004134 @default.
• W3012495265 cites W2304025542 @default.
• W3012495265 cites W2322099511 @default.
• W3012495265 cites W2322963326 @default.
• W3012495265 cites W2327055127 @default.
• W3012495265 cites W2330587564 @default.
• W3012495265 cites W2346390990 @default.
• W3012495265 cites W2381691383 @default.
• W3012495265 cites W2418769740 @default.
• W3012495265 cites W2517085860 @default.
• W3012495265 cites W2522763741 @default.
• W3012495265 cites W2527654830 @default.
• W3012495265 cites W2541285986 @default.
• W3012495265 cites W2546531144 @default.
• W3012495265 cites W2547031711 @default.
• W3012495265 cites W2553484608 @default.
• W3012495265 cites W2588408561 @default.
• W3012495265 cites W2594365286 @default.
• W3012495265 cites W2595110790 @default.
• W3012495265 cites W2603684260 @default.
• W3012495265 cites W2631673659 @default.
• W3012495265 cites W2664605305 @default.
• W3012495265 cites W2741959390 @default.
• W3012495265 cites W2752700145 @default.
• W3012495265 cites W2768010984 @default.
• W3012495265 cites W2771797851 @default.
• W3012495265 cites W2773137913 @default.
• W3012495265 cites W2779386549 @default.
• W3012495265 cites W2789418706 @default.
• W3012495265 cites W2790010984 @default.
• W3012495265 cites W2790275773 @default.
• W3012495265 cites W2791370447 @default.
• W3012495265 cites W2791671940 @default.
• W3012495265 cites W2793376319 @default.
• W3012495265 cites W2794329512 @default.
• W3012495265 cites W2796940952 @default.

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