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• W3012511500 abstract "Elderly patients are particularly susceptible to the development of acute kidney injury (AKI) due to aging process, the presence of comorbidities, and the reduced ability to recover. AKI is associated with considerable mortality among hospitalized elderly patients. The current treatment for AKI is mainly supportive in nature; no specific therapeutic modalities to date have shown efficacy in treating the condition. It is important to identify the high risk individuals who are more susceptible to AKI. This study aimed to screen and identify the urinary risk markers in elderly patients, which are related to increased susceptibility to AKI after cardiac surgery. Patients aged ≥60 were selected who were admitted to the Cardial Surgery Department from October 2017 to October 2018. Baseline blood and urine specimens of the patients were collected within 48 h after admission. All the patients did not have past history of kidney diseases. Patients with preoperative oliguria, post-renal obstruction and those requiring emergency surgery were excluded. 6 patients from AKI group and control group were selected for Protein Microarrays - RayBiotech analysis. The differential proteins between groups were further verified using Enzyme linked immunosorbent assay (ELISA) in another AKI and control elderly patients, which included 30 patients in each group. ROC curve analysis was also carried out, so as to further determine its significance in predicting susceptibility to AKI. There were no significant difference according to the baseline clinical informations and lab tests between the AKI and control groups, except eGFR, which showed relatively lower in the AKI group (69.99±18.71 vs 79.59±13.34 ml/min/1.73m2, p＜0.05). 87 differential proteins with the average difference of >5-fold were screened by the high through-put protein chip analysis between AKI group and control group, in which 86 proteins were elevated and 1 were reduced (P<0.05). Four proteins (HSP27, IGFBP-1, Clusterin, Galectin-1) were confirmed by ELISA. The urine supernatant clusterin level in AKI group was higher than that in control group（6.504±4.446 vs 3.702±3.904 ng/μmol，p＜0.05）. Another group of 60 elderly patients were chosen for external validation by ELISA. The areas under the ROC curve (AUC) of clusterin, eGFR, clusterin+eGFR in predicting postoperative AKI were 0.706, 0.642 and 0.724, respectively. Clusterin is a protein expressed on tubular cells which has been suggested to play an antiapoptotic role and to be involved in cell protection. This study demontstrated the baseline clusterin level in urine supernatant as a promising biomarker for prediction of susceptibility to AKI. which has good accuracy and can be used to identify high risk elderly patients." @default.
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• W3012511500 date "2020-03-01" @default.
• W3012511500 modified "2023-09-25" @default.
• W3012511500 title "SUN-029 URINE SUPERNATANT CLUSTERIN IS A PREDICTING BIOMARKER FOR ENHANCED SUSCEPTIBILITY TO ACUTE KIDNEY INJURY IN THE ELDERLY AFTER CARDIAC SURGERY" @default.
• W3012511500 doi "https://doi.org/10.1016/j.ekir.2020.02.552" @default.
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