Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012552305> ?p ?o ?g. }
- W3012552305 endingPage "113691" @default.
- W3012552305 startingPage "113691" @default.
- W3012552305 abstract "Membraneless organelles (MLOs) in the cytoplasm and nucleus in the form of 2D and 3D phase-separated biomolecular condensates are increasingly viewed as critical in regulating diverse cellular functions. These functions include cell signaling, immune synapse function, nuclear transcription, RNA splicing and processing, mRNA storage and translation, virus replication and maturation, antiviral mechanisms, DNA sensing, synaptic transmission, protein turnover and mitosis. Components comprising MLOs often associate with low affinity; thus cell integrity can be critical to the maintenance of the full complement of respective MLO components. Phase-separated condensates are typically metastable (shape-changing) and can undergo dramatic, rapid and reversible assembly and disassembly in response to cell signaling events, cell stress, during mitosis, and after changes in cytoplasmic “crowding” (as observed with condensates of the human myxovirus resistance protein MxA). Increasing evidence suggests that neuron-specific aberrations in phase-separation properties of RNA-binding proteins (e.g. FUS and TDP-43) and others (such as the microtubule-binding protein tau) contribute to the development of degenerative neurological diseases (e.g. amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease). Thus, studies of liquid-like phase separation (LLPS) and the formation, structure and function of MLOs are of considerable importance in understanding basic cell biology and the pathogenesis of human diseases." @default.
- W3012552305 created "2020-03-23" @default.
- W3012552305 creator A5031605679 @default.
- W3012552305 creator A5045422081 @default.
- W3012552305 creator A5064719174 @default.
- W3012552305 creator A5065396756 @default.
- W3012552305 creator A5067464866 @default.
- W3012552305 date "2020-05-01" @default.
- W3012552305 modified "2023-10-04" @default.
- W3012552305 title "Biomolecular condensates in cell biology and virology: Phase-separated membraneless organelles (MLOs)" @default.
- W3012552305 cites W1894813487 @default.
- W3012552305 cites W1968975193 @default.
- W3012552305 cites W1984893779 @default.
- W3012552305 cites W1989826291 @default.
- W3012552305 cites W1991140361 @default.
- W3012552305 cites W1991436313 @default.
- W3012552305 cites W2003119180 @default.
- W3012552305 cites W2026226960 @default.
- W3012552305 cites W2030929691 @default.
- W3012552305 cites W2054352933 @default.
- W3012552305 cites W2081563673 @default.
- W3012552305 cites W2083112247 @default.
- W3012552305 cites W2090023448 @default.
- W3012552305 cites W2096009548 @default.
- W3012552305 cites W2114654756 @default.
- W3012552305 cites W2116239308 @default.
- W3012552305 cites W2120482891 @default.
- W3012552305 cites W2122823449 @default.
- W3012552305 cites W2139194392 @default.
- W3012552305 cites W2139585356 @default.
- W3012552305 cites W2141420286 @default.
- W3012552305 cites W2153675295 @default.
- W3012552305 cites W2222857089 @default.
- W3012552305 cites W2501424458 @default.
- W3012552305 cites W2590568317 @default.
- W3012552305 cites W2646467224 @default.
- W3012552305 cites W2731724500 @default.
- W3012552305 cites W2747187816 @default.
- W3012552305 cites W2756821926 @default.
- W3012552305 cites W2788827529 @default.
- W3012552305 cites W2790755828 @default.
- W3012552305 cites W2800004384 @default.
- W3012552305 cites W2809057270 @default.
- W3012552305 cites W2809092342 @default.
- W3012552305 cites W2810246680 @default.
- W3012552305 cites W2838851331 @default.
- W3012552305 cites W2854081253 @default.
- W3012552305 cites W2884082692 @default.
- W3012552305 cites W2887994055 @default.
- W3012552305 cites W2891317436 @default.
- W3012552305 cites W2901758876 @default.
- W3012552305 cites W2902026154 @default.
- W3012552305 cites W2903264039 @default.
- W3012552305 cites W2905220927 @default.
- W3012552305 cites W2906593639 @default.
- W3012552305 cites W2907119067 @default.
- W3012552305 cites W2913767184 @default.
- W3012552305 cites W2921239313 @default.
- W3012552305 cites W2921733160 @default.
- W3012552305 cites W2922246560 @default.
- W3012552305 cites W2924206910 @default.
- W3012552305 cites W2934039982 @default.
- W3012552305 cites W2952564407 @default.
- W3012552305 cites W2956385297 @default.
- W3012552305 cites W2956906556 @default.
- W3012552305 cites W2966263591 @default.
- W3012552305 cites W2966957401 @default.
- W3012552305 cites W2969743565 @default.
- W3012552305 cites W2970894940 @default.
- W3012552305 cites W2971693658 @default.
- W3012552305 cites W2980440719 @default.
- W3012552305 cites W2980631159 @default.
- W3012552305 cites W2981963645 @default.
- W3012552305 cites W2985592471 @default.
- W3012552305 cites W2996870716 @default.
- W3012552305 cites W3002736232 @default.
- W3012552305 cites W3004009934 @default.
- W3012552305 cites W3004533093 @default.
- W3012552305 cites W3011060644 @default.
- W3012552305 cites W3011387478 @default.
- W3012552305 doi "https://doi.org/10.1016/j.ab.2020.113691" @default.
- W3012552305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32194074" @default.
- W3012552305 hasPublicationYear "2020" @default.
- W3012552305 type Work @default.
- W3012552305 sameAs 3012552305 @default.
- W3012552305 citedByCount "34" @default.
- W3012552305 countsByYear W30125523052020 @default.
- W3012552305 countsByYear W30125523052021 @default.
- W3012552305 countsByYear W30125523052022 @default.
- W3012552305 countsByYear W30125523052023 @default.
- W3012552305 crossrefType "journal-article" @default.
- W3012552305 hasAuthorship W3012552305A5031605679 @default.
- W3012552305 hasAuthorship W3012552305A5045422081 @default.
- W3012552305 hasAuthorship W3012552305A5064719174 @default.
- W3012552305 hasAuthorship W3012552305A5065396756 @default.
- W3012552305 hasAuthorship W3012552305A5067464866 @default.
- W3012552305 hasConcept C104317684 @default.
- W3012552305 hasConcept C105580179 @default.