Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012561729> ?p ?o ?g. }
- W3012561729 endingPage "141" @default.
- W3012561729 startingPage "141" @default.
- W3012561729 abstract "Leishmania infantum parasites cause a severe form of visceral leishmaniasis in human and viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an attenuated L. infantum cell line, lacking the hsp70-II gene, protects against the development of murine cutaneous leishmaniasis. In this work, we analyzed the vaccine potential of this cell line towards the long-term protection against murine visceral leishmaniasis. This model shows an organ-dependent evolution of the disease. The infection can resolve in the liver but chronically affect spleen and bone marrow. Twelve weeks after subcutaneous administration of attenuated L. infantum, Bagg Albino (BALB/c) mice were challenged with infective L. infantum parasites expressing the luciferase-encoding gene. Combining in vivo bioimaging techniques with limiting dilution experiments, we report that, in the initial phase of the disease, vaccinated animals presented lower parasite loads than unvaccinated animals. A reduction of the severity of liver damage was also detected. Protection was associated with the induction of rapid parasite-specific IFN-γ production by CD4+ and CD8+ T cells. However, the vaccine was unable to control the chronic phase of the disease, since we did not find differences in the parasite burdens nor in the immune response at that time point." @default.
- W3012561729 created "2020-03-27" @default.
- W3012561729 creator A5004510987 @default.
- W3012561729 creator A5006387926 @default.
- W3012561729 creator A5011180594 @default.
- W3012561729 creator A5012601470 @default.
- W3012561729 creator A5019058082 @default.
- W3012561729 creator A5021320548 @default.
- W3012561729 creator A5031703629 @default.
- W3012561729 creator A5048071213 @default.
- W3012561729 creator A5062945956 @default.
- W3012561729 creator A5063080095 @default.
- W3012561729 creator A5076159994 @default.
- W3012561729 creator A5077929748 @default.
- W3012561729 creator A5081737102 @default.
- W3012561729 date "2020-03-23" @default.
- W3012561729 modified "2023-09-30" @default.
- W3012561729 title "Subcutaneous Immunization of Leishmania HSP70-II Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice" @default.
- W3012561729 cites W1607721371 @default.
- W3012561729 cites W1730123569 @default.
- W3012561729 cites W1891326432 @default.
- W3012561729 cites W1993498133 @default.
- W3012561729 cites W1995127073 @default.
- W3012561729 cites W2003948064 @default.
- W3012561729 cites W2019822340 @default.
- W3012561729 cites W2022333100 @default.
- W3012561729 cites W2026286437 @default.
- W3012561729 cites W2033785669 @default.
- W3012561729 cites W2034870434 @default.
- W3012561729 cites W2035019807 @default.
- W3012561729 cites W2038850624 @default.
- W3012561729 cites W2041858338 @default.
- W3012561729 cites W2045603426 @default.
- W3012561729 cites W2055579893 @default.
- W3012561729 cites W2063680727 @default.
- W3012561729 cites W2070801999 @default.
- W3012561729 cites W2084424946 @default.
- W3012561729 cites W2092793728 @default.
- W3012561729 cites W2101232322 @default.
- W3012561729 cites W2102941078 @default.
- W3012561729 cites W2105403778 @default.
- W3012561729 cites W2107255267 @default.
- W3012561729 cites W2107915297 @default.
- W3012561729 cites W2110078092 @default.
- W3012561729 cites W2112968886 @default.
- W3012561729 cites W2116717421 @default.
- W3012561729 cites W2120509159 @default.
- W3012561729 cites W2125038701 @default.
- W3012561729 cites W2136384724 @default.
- W3012561729 cites W2140736098 @default.
- W3012561729 cites W2141057399 @default.
- W3012561729 cites W2141360780 @default.
- W3012561729 cites W2150414340 @default.
- W3012561729 cites W2152226557 @default.
- W3012561729 cites W2165588026 @default.
- W3012561729 cites W2166171364 @default.
- W3012561729 cites W2172156604 @default.
- W3012561729 cites W2215373933 @default.
- W3012561729 cites W2242441917 @default.
- W3012561729 cites W2289229009 @default.
- W3012561729 cites W2293820371 @default.
- W3012561729 cites W2294083761 @default.
- W3012561729 cites W2515503869 @default.
- W3012561729 cites W2573267280 @default.
- W3012561729 cites W2617846904 @default.
- W3012561729 cites W2624285072 @default.
- W3012561729 cites W2782928093 @default.
- W3012561729 cites W2791885900 @default.
- W3012561729 cites W2795029241 @default.
- W3012561729 cites W2805589237 @default.
- W3012561729 cites W2884969376 @default.
- W3012561729 cites W2898148188 @default.
- W3012561729 cites W2914377013 @default.
- W3012561729 cites W2944556830 @default.
- W3012561729 cites W2948178361 @default.
- W3012561729 cites W2952827834 @default.
- W3012561729 cites W2964991854 @default.
- W3012561729 cites W2972731071 @default.
- W3012561729 cites W2979963851 @default.
- W3012561729 cites W2980449436 @default.
- W3012561729 cites W604736134 @default.
- W3012561729 doi "https://doi.org/10.3390/vaccines8010141" @default.
- W3012561729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7157689" @default.
- W3012561729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32210040" @default.
- W3012561729 hasPublicationYear "2020" @default.
- W3012561729 type Work @default.
- W3012561729 sameAs 3012561729 @default.
- W3012561729 citedByCount "13" @default.
- W3012561729 countsByYear W30125617292021 @default.
- W3012561729 countsByYear W30125617292022 @default.
- W3012561729 countsByYear W30125617292023 @default.
- W3012561729 crossrefType "journal-article" @default.
- W3012561729 hasAuthorship W3012561729A5004510987 @default.
- W3012561729 hasAuthorship W3012561729A5006387926 @default.
- W3012561729 hasAuthorship W3012561729A5011180594 @default.
- W3012561729 hasAuthorship W3012561729A5012601470 @default.
- W3012561729 hasAuthorship W3012561729A5019058082 @default.
- W3012561729 hasAuthorship W3012561729A5021320548 @default.