FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012632338> ?p ?o ?g. }

• W3012632338 abstract "Abstract Background Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) results in a 3–5-fold increase in the risk of hospital mortality compared to sepsis alone. The development of therapies to reverse S-AKI could therefore significantly affect sepsis outcomes. However, the translation of therapies from preclinical studies into humans requires model systems that recapitulate clinical scenarios and the development of renal fibrosis indicative of the transition from acute to chronic kidney disease. Results Here we characterized a murine model of S-AKI induced by abdominal sepsis developing into a chronic phenotype. We applied a small molecule histone deacetylase-8 inhibitor, UPHD186, and found that early treatment, beginning at 48 h post-sepsis, worsened renal outcome accompanied by decreasing mononuclear cell infiltration in the kidney, skewing cells into a pro-inflammatory phenotype, and increased pro-fibrotic gene expression, while delayed treatment, beginning at 96 h post-sepsis, after the acute inflammation in the kidney had subsided, resulted in improved survival and kidney histology presumably through promoting proliferation and inhibiting fibrosis. Conclusions These findings not only present a clinically relevant S-AKI model, but also introduce a timing dimension into S-AKI therapeutic interventions that delayed treatment with UPHD186 may enhance renal histologic repair. Our results provide novel insights into successful repair of kidney injury and sepsis therapy." @default.
• W3012632338 created "2020-03-27" @default.
• W3012632338 creator A5021022035 @default.
• W3012632338 creator A5026231812 @default.
• W3012632338 creator A5038463777 @default.
• W3012632338 creator A5045254331 @default.
• W3012632338 creator A5063318825 @default.
• W3012632338 creator A5080272499 @default.
• W3012632338 creator A5085073172 @default.
• W3012632338 date "2020-02-07" @default.
• W3012632338 modified "2023-10-17" @default.
• W3012632338 title "Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury" @default.
• W3012632338 cites W1965699247 @default.
• W3012632338 cites W1980654946 @default.
• W3012632338 cites W1984061476 @default.
• W3012632338 cites W2003081532 @default.
• W3012632338 cites W2008420298 @default.
• W3012632338 cites W2022737552 @default.
• W3012632338 cites W2023945291 @default.
• W3012632338 cites W2054938569 @default.
• W3012632338 cites W2064437293 @default.
• W3012632338 cites W2066887945 @default.
• W3012632338 cites W2077967941 @default.
• W3012632338 cites W2088407814 @default.
• W3012632338 cites W2096197939 @default.
• W3012632338 cites W2099344722 @default.
• W3012632338 cites W2101524200 @default.
• W3012632338 cites W2105199836 @default.
• W3012632338 cites W2108017291 @default.
• W3012632338 cites W2112635820 @default.
• W3012632338 cites W2116352783 @default.
• W3012632338 cites W2117048312 @default.
• W3012632338 cites W2122327137 @default.
• W3012632338 cites W2130756984 @default.
• W3012632338 cites W2143986203 @default.
• W3012632338 cites W2148152947 @default.
• W3012632338 cites W2148353698 @default.
• W3012632338 cites W2156200233 @default.
• W3012632338 cites W2156935689 @default.
• W3012632338 cites W2158079337 @default.
• W3012632338 cites W2160005456 @default.
• W3012632338 cites W2168729190 @default.
• W3012632338 cites W2168784022 @default.
• W3012632338 cites W2169504018 @default.
• W3012632338 cites W2171175193 @default.
• W3012632338 cites W2280404143 @default.
• W3012632338 cites W2297152275 @default.
• W3012632338 cites W2300871243 @default.
• W3012632338 cites W2339371539 @default.
• W3012632338 cites W2520697268 @default.
• W3012632338 cites W2560129407 @default.
• W3012632338 cites W2563393230 @default.
• W3012632338 cites W2576066242 @default.
• W3012632338 cites W2582602949 @default.
• W3012632338 cites W2611455804 @default.
• W3012632338 cites W2620241325 @default.
• W3012632338 cites W2623546284 @default.
• W3012632338 cites W2778834997 @default.
• W3012632338 cites W2785291160 @default.
• W3012632338 cites W2793011605 @default.
• W3012632338 cites W2793549597 @default.
• W3012632338 cites W2794185796 @default.
• W3012632338 cites W2804243706 @default.
• W3012632338 cites W2806116714 @default.
• W3012632338 cites W2882972792 @default.
• W3012632338 cites W2883732244 @default.
• W3012632338 cites W2908936829 @default.
• W3012632338 cites W2963730652 @default.
• W3012632338 cites W4255535345 @default.
• W3012632338 doi "https://doi.org/10.1186/s40635-020-0297-3" @default.
• W3012632338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7007462" @default.
• W3012632338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32034542" @default.
• W3012632338 hasPublicationYear "2020" @default.
• W3012632338 type Work @default.
• W3012632338 sameAs 3012632338 @default.
• W3012632338 citedByCount "11" @default.
• W3012632338 countsByYear W30126323382020 @default.
• W3012632338 countsByYear W30126323382021 @default.
• W3012632338 countsByYear W30126323382022 @default.
• W3012632338 countsByYear W30126323382023 @default.
• W3012632338 crossrefType "journal-article" @default.
• W3012632338 hasAuthorship W3012632338A5021022035 @default.
• W3012632338 hasAuthorship W3012632338A5026231812 @default.
• W3012632338 hasAuthorship W3012632338A5038463777 @default.
• W3012632338 hasAuthorship W3012632338A5045254331 @default.
• W3012632338 hasAuthorship W3012632338A5063318825 @default.
• W3012632338 hasAuthorship W3012632338A5080272499 @default.
• W3012632338 hasAuthorship W3012632338A5085073172 @default.
• W3012632338 hasBestOaLocation W30126323381 @default.
• W3012632338 hasConcept C126322002 @default.
• W3012632338 hasConcept C203014093 @default.
• W3012632338 hasConcept C2776914184 @default.
• W3012632338 hasConcept C2778384902 @default.
• W3012632338 hasConcept C2778426790 @default.
• W3012632338 hasConcept C2778653478 @default.
• W3012632338 hasConcept C2780091579 @default.
• W3012632338 hasConcept C2780472472 @default.
• W3012632338 hasConcept C2780559512 @default.
• W3012632338 hasConcept C71924100 @default.
• W3012632338 hasConceptScore W3012632338C126322002 @default.

• next