FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012640775> ?p ?o ?g. }

• W3012640775 endingPage "387" @default.
• W3012640775 startingPage "377" @default.
• W3012640775 abstract "CUDC-907 is a novel dual-acting inhibitor of phosphoinositide 3-kinase (PI3K) and histone deacetylase (HDAC). In this study, we aimed to explore the anticancer effects of CUDC-907 on human breast cancer cells. Our results showed that CUDC-907 effectively inhibited breast cancer cell proliferation. Flow cytometry analysis revealed that CUDC-907 induced cell cycle arrest and apoptosis in breast cancer cells. The combined treatment of CUDC-907 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resulted in a marked increase in apoptosis and cleavage of caspase-8, −9 and poly (ADP-ribose) polymerase (PARP) in breast cancer cells. CUDC-907 enhanced expressions of death receptor 5 (DR5), reduced the levels of anti-apoptotic molecules XIAP, Bcl-2 and Bcl-xL. Knockdown of DR5 abrogated apoptosis induced by the combination of CUDC-907 and TRAIL in breast cancer cells. CUDC-907 increased the phosphorylation of JNK and p38 MAPK. JNK inhibitor pretreatment attenuated CUDC-907-induced upregulation of DR5. In summary, CUDC-907 shows potent cytotoxicity against breast cancer cells and facilitates TRAIL-mediated apoptosis through DR5 upregulation. The combination of CUDC-907 and TRAIL may be a promising therapeutic approach in the treatment of breast cancer." @default.
• W3012640775 created "2020-03-27" @default.
• W3012640775 creator A5028115272 @default.
• W3012640775 creator A5031950094 @default.
• W3012640775 creator A5041469228 @default.
• W3012640775 creator A5047036161 @default.
• W3012640775 creator A5057282648 @default.
• W3012640775 creator A5077029241 @default.
• W3012640775 date "2020-03-21" @default.
• W3012640775 modified "2023-10-15" @default.
• W3012640775 title "CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells" @default.
• W3012640775 cites W1483336235 @default.
• W3012640775 cites W2006068954 @default.
• W3012640775 cites W2098509343 @default.
• W3012640775 cites W2107661677 @default.
• W3012640775 cites W2164689082 @default.
• W3012640775 cites W2272984102 @default.
• W3012640775 cites W2283312895 @default.
• W3012640775 cites W2511667040 @default.
• W3012640775 cites W2561238268 @default.
• W3012640775 cites W2582131052 @default.
• W3012640775 cites W2593447120 @default.
• W3012640775 cites W2610183300 @default.
• W3012640775 cites W2620490360 @default.
• W3012640775 cites W2621935633 @default.
• W3012640775 cites W2735361290 @default.
• W3012640775 cites W2753507521 @default.
• W3012640775 cites W2765367174 @default.
• W3012640775 cites W2774680971 @default.
• W3012640775 cites W2779678403 @default.
• W3012640775 cites W2789657762 @default.
• W3012640775 cites W2800561892 @default.
• W3012640775 cites W2804618430 @default.
• W3012640775 cites W2805565785 @default.
• W3012640775 cites W2809509612 @default.
• W3012640775 cites W2888349835 @default.
• W3012640775 cites W2898524339 @default.
• W3012640775 cites W2899003114 @default.
• W3012640775 cites W2906705500 @default.
• W3012640775 cites W2907486571 @default.
• W3012640775 cites W2916665060 @default.
• W3012640775 cites W2963418546 @default.
• W3012640775 cites W4251409220 @default.
• W3012640775 doi "https://doi.org/10.1007/s12079-020-00558-3" @default.
• W3012640775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7642015" @default.
• W3012640775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32200503" @default.
• W3012640775 hasPublicationYear "2020" @default.
• W3012640775 type Work @default.
• W3012640775 sameAs 3012640775 @default.
• W3012640775 citedByCount "15" @default.
• W3012640775 countsByYear W30126407752020 @default.
• W3012640775 countsByYear W30126407752021 @default.
• W3012640775 countsByYear W30126407752022 @default.
• W3012640775 countsByYear W30126407752023 @default.
• W3012640775 crossrefType "journal-article" @default.
• W3012640775 hasAuthorship W3012640775A5028115272 @default.
• W3012640775 hasAuthorship W3012640775A5031950094 @default.
• W3012640775 hasAuthorship W3012640775A5041469228 @default.
• W3012640775 hasAuthorship W3012640775A5047036161 @default.
• W3012640775 hasAuthorship W3012640775A5057282648 @default.
• W3012640775 hasAuthorship W3012640775A5077029241 @default.
• W3012640775 hasBestOaLocation W30126407752 @default.
• W3012640775 hasConcept C104317684 @default.
• W3012640775 hasConcept C121608353 @default.
• W3012640775 hasConcept C127561419 @default.
• W3012640775 hasConcept C190283241 @default.
• W3012640775 hasConcept C203014093 @default.
• W3012640775 hasConcept C31573885 @default.
• W3012640775 hasConcept C33195913 @default.
• W3012640775 hasConcept C502942594 @default.
• W3012640775 hasConcept C530470458 @default.
• W3012640775 hasConcept C54355233 @default.
• W3012640775 hasConcept C55493867 @default.
• W3012640775 hasConcept C86554907 @default.
• W3012640775 hasConcept C86803240 @default.
• W3012640775 hasConcept C96232424 @default.
• W3012640775 hasConcept C98424977 @default.
• W3012640775 hasConceptScore W3012640775C104317684 @default.
• W3012640775 hasConceptScore W3012640775C121608353 @default.
• W3012640775 hasConceptScore W3012640775C127561419 @default.
• W3012640775 hasConceptScore W3012640775C190283241 @default.
• W3012640775 hasConceptScore W3012640775C203014093 @default.
• W3012640775 hasConceptScore W3012640775C31573885 @default.
• W3012640775 hasConceptScore W3012640775C33195913 @default.
• W3012640775 hasConceptScore W3012640775C502942594 @default.
• W3012640775 hasConceptScore W3012640775C530470458 @default.
• W3012640775 hasConceptScore W3012640775C54355233 @default.
• W3012640775 hasConceptScore W3012640775C55493867 @default.
• W3012640775 hasConceptScore W3012640775C86554907 @default.
• W3012640775 hasConceptScore W3012640775C86803240 @default.
• W3012640775 hasConceptScore W3012640775C96232424 @default.
• W3012640775 hasConceptScore W3012640775C98424977 @default.
• W3012640775 hasFunder F4320321001 @default.
• W3012640775 hasFunder F4320324174 @default.
• W3012640775 hasIssue "4" @default.
• W3012640775 hasLocation W30126407751 @default.
• W3012640775 hasLocation W30126407752 @default.
• W3012640775 hasLocation W30126407753 @default.

• next