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- W3012678974 abstract "Abstract Background Autotetraploid Carassius auratus (4nRCC, 4n = 200, RRRR) was derived from the whole genome duplication of diploid red crucian carp ( Carassius auratus red var.) (2nRCC, 2n = 100, RR). To investigate the genetic effects of tetraploidization, we analyzed DNA variation, epigenetic modification and gene expression changes in the Sox9a - Amh - Cyp19a1a regulatory cascade between 4nRCC and 2nRCC. Results We found that the Sox9a gene contained two variants in 2nRCC and four variants in 4nRCC. Compared with that in 2nRCC, DNA methylation in the promoter regions of the Amh and Cyp19a1a genes in 4nRCC was altered by single nucleotide polymorphism (SNP) mutations, which resulted in the insertions and deletions of CpG sites, and the methylation levels of the Sox9a , Amh and Cyp19a1a genes increased after tetraploidization. The gene expression level of the Sox9a - Amh - Cyp19a1a regulatory cascade was downregulated in 4nRCC compared with that in 2nRCC. Conclusion The above results demonstrate that tetraploidization leads to significant changes in the genome, epigenetic modification and gene expression in the Sox9a - Amh - Cyp19a1a regulatory cascade; these findings increase the extant knowledge regarding the effects of polyploidization." @default.
- W3012678974 created "2020-03-27" @default.
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- W3012678974 date "2020-03-21" @default.
- W3012678974 modified "2023-10-06" @default.
- W3012678974 title "Comparative analyses of the Sox9a-Amh-Cyp19a1a regulatory Cascade in Autotetraploid fish and its diploid parent" @default.
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- W3012678974 doi "https://doi.org/10.1186/s12863-020-00840-8" @default.
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