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• W3012703597 abstract "Abstract Objective Adolescence is a period of rapid brain development when symptoms of mood, anxiety, and other disorders often first emerge, suggesting disruptions in maturing reward circuitry may play a role in mental illness onset. Here, we characterized associations between resting-state network properties and psychiatric symptomatology in medication-free adolescents with a wide range of symptom severity. Methods Adolescents (age 12-20) with mood and/or anxiety symptoms (n=68) and healthy controls (n=19) completed diagnostic interviews, depression/anhedonia/anxiety questionnaires, and 3T resting-state fMRI (10min/2.3mm/TR=1s). Data were preprocessed (HCP Pipelines), aligned (MSMAll), and parcellated into 750 nodes encompassing the entire cortex/subcortex (Cole-Anticevic Brain-wide Network Partition). Weighted graph theoretical metrics (Strength Centrality=C Str ; Eigenvector Centrality=C Eig ; Local Efficiency=E Loc ) were estimated within Whole Brain and task-derived Reward Anticipation / Attainment / Prediction Error networks. Associations with clinical status and symptoms were assessed non-parametrically (two-tailed p FWE <0.05). Results Relative to controls, clinical adolescents had increased ventral striatum C Eig within the Reward Attainment network. Across subjects, depression correlated with subgenual cingulate C Str and E Loc , anhedonia correlated with ventromedial prefrontal C Str and lateral amygdala E Loc , and anxiety negatively correlated with parietal operculum C Eig and medial amygdala E Loc within the Whole Brain network. Conclusions Using a data-driven analysis approach, high-quality parcellation, and clinically diverse adolescent cohort, we found that symptoms within positive and negative valence system constructs differentially associated with resting-state network abnormalities: depression and anhedonia, as well as clinical status, involved greater influence and communication efficiency in prefrontal and limbic reward areas, whereas anxiety was linked to reduced influence/efficiency in amygdala and cortical regions involved in stimulus monitoring." @default.
• W3012703597 created "2020-03-27" @default.
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• W3012703597 date "2020-03-23" @default.
• W3012703597 modified "2023-10-11" @default.
• W3012703597 title "Neural Correlates of Positive and Negative Valence System Dysfunction in Adolescents Revealed by Data-Driven Parcellation and Resting-State Network Modeling" @default.
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• W3012703597 doi "https://doi.org/10.1101/2020.03.20.001032" @default.
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