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• W3012716276 abstract "Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression and metastasis of colorectal cancer. The inconsistency of the results in different cancers has led to uncertainty regarding the role of JAM-B in carcinogenesis. For this purpose, the expression levels of JAM-B in pancreatic cancer (PanCa) tissues were associated with T stage and lymph node involvement with significant differences. A relatively high expression of JAM-B was found in PanCa cell lines by immunohistochemistry and western blot analysis. By cell transfection, JAM-B was silenced in tumor cell lines to determine cell invasion and migration abilities. Scratch wound assays and Transwell assays revealed that shJAM-B significantly decreased Panc-1 cell migration and invasion. Experiments were also conducted using a subcutaneous PanCa nude mouse model. A significant difference in tumor diameter at the injection site was found between the control group and the JAM-B low expression group. The expression levels of c-Src and MMP9 were also significantly reduced compared to that in the control group by immunohistochemistry. In conclusion, our results suggest that JAM-B secreted by cancer cells can promote progression and invasion in PanCa by upregulating the c-Src signal and related downstream proteins." @default.
• W3012716276 created "2020-03-27" @default.
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• W3012716276 date "2020-01-01" @default.
• W3012716276 modified "2023-09-23" @default.
• W3012716276 title "The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer." @default.
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• W3012716276 doi "https://doi.org/10.7150/jca.40953" @default.
• W3012716276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7097935" @default.
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