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• W3012745109 abstract "Whole-Genome Analysis of Two Copies of blaNDM-1 Gene Carrying Acinetobacter johnsonii Strain Acsw19 Isolated from Sichuan, China Lingtong Tang,1,2 Wei Shen,2,3 Zhikun Zhang,2 Jingping Zhang,2 Guangxi Wang,2 Li Xiang,2 Junping She,2 Xiaoyan Hu,2 Guoyuan Zou,4 Baoli Zhu,5 Yingshun Zhou2 1Department of Clinical Laboratory, The People’s Hospital of Gao County, Sichuan 644000, People’s Republic of China; 2Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 3Department of Clinical Laboratory, The First People’s Hospital of Yibin, Yibin 644000, Sichuan, People’s Republic of China; 4Institute of Plant Nutrition and Resources, Beijing Academy of Agriculture and Forestry Science, Beijing, People’s Republic of China; 5Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaCorrespondence: Yingshun ZhouDepartment of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, No. 319, Zhongshan Road, Luzhou 646000, Sichuan, People’s Republic of ChinaTel +86– 0830– 3160073Email yingshunzhou@swmu.edu.cnGuoyuan ZouInstitute of Plant Nutrition and Resources, Beijing Academy of Agriculture and Forestry Science, Beijing, People’s Republic of ChinaEmail gyzou@163.comPurpose: To characterize the genetic feature of the carbapenems resistant Acinetobacter johnsonii strain Acsw19 isolated from municipal sludge. This strain was found to carry two copies of blaNDM-1, cmlB1-like gene, and blaOXA-211-like gene along with other 8 antimicrobial resistance genes, 3 plasmids, 15 genomic islands and 8 prophages.Methods: A carbapenem-resistant Acinetobacter johnsonii strain Acsw19 isolated from municipal sludge was subjected to whole-genome sequencing (WGS) via the PacBio and Illumina MiSeq platforms. Thereafter, the characteristic was analyzed by a series of bioinformatics software.Results: The results showed that the genome of Acsw19 was consisted of a 3,433,749 bp circular chromosome and 3 circular plasmids, pAcsw19-1 (11,161 bp), pAcsw19-2 (351,885 bp) and pAcsw19-3 (38,391bp), respectively. Resistome analysis showed that Acsw19 carried 12 antimicrobial resistance genes, including 6 [cmlB1-like, blaNDM-1, blaOXA-58, aph ( 3ʹ)-VIa, msr(E) and mph(E)] in the plasmid pAcsw19-2 and 6 (blaOXA-211-like, blaNDM-1, aph(3)-Ib, aph(6)-Id, sul2, and floR) in the chromosome genome. Specifically, the cmlB1-like gene shared 86.33%, 71.7% and 71.9% similarities with the cmlB1, cmlA4 and cmlA8 gene, and the blaOXA-211-like gene shared 94.4%, 95.39% and 96.36% similarities with blaOXA-211, blaOXA-643 and blaOXA-652, at the nucleotide level, respectively. Phylogenetic analysis showed that the blaOXA-211-like gene and cmlB1-like gene had the closest evolutionary relationship with blaOXA-643 and cmlB1, respectively. These results indicated that the blaOXA-211-like and cmlB1-like genes identified in the current study should be the novel variant resistance genes.Conclusion: Carrying of two copies of blaNDM-1, cmlB1-like, blaOXA-211-like and along with other 8 antimicrobial resistance genes, 3 plasmids, 15 genomic islands and 8 prophages Acinetobacter johnsonii strain might increase the possibility of spreading of resistance genes.Keywords: Acinetobacter johnsonii, blaNDM-1, blaOXA, genomic island" @default.
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• W3012745109 date "2020-03-01" @default.
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• W3012745109 title "<p>Whole-Genome Analysis of Two Copies of <em>bla</em>_NDM-1 Gene Carrying <em>Acinetobacter johnsonii</em> Strain Acsw19 Isolated from Sichuan, China</p>" @default.
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• W3012745109 doi "https://doi.org/10.2147/idr.s236200" @default.
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