Matches in SemOpenAlex for { <https://semopenalex.org/work/W301285140> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W301285140 abstract "The 5{prime} flanking polymorphism (5{prime}FP), a hypervariable region at the 5{prime} end of the insulin gene, has {open_quotes}class 1{close_quotes} alleles (650-900 bp long) that are in positive linkage disequilibrium with insulin-dependent diabetes mellitus (IDDM). The authors report that precise sizing of the 5{prime}FP yields a bimodal frequency distribution of class 1 allele lengths. Class 1 alleles belonging to the lower component (650-750 bp) of the bimodal distribution were somewhat more highly associated with IDDM than were alleles from the upper component (760-900 bp), but the difference was not statistically significant. They also examined 5{prime}FP length variation in relation to allelic variation at nearby polymorphisms. At biallelic RFLPs on both sides of the 5{prime}FP, they found that one allele exhibits near-total association with the upper component of the 5FP class 1 distribution. Such associations represent a little-known but potentially wide-spread form of linkage disequilibrium. In this type of disequilibrium, a flanking allele has near-complete association with a single mode of VNTR alleles whose lengths represent consecutive numbers of tandem repeats (CNTR). Such extreme disequilibrium between a CNTR mode and flanking alleles may originate and persist because length mutations at some VNTR loci usually add or delete only one or two repeatmore » units. 22 refs., 5 figs., 6 tabs.« less" @default.
- W301285140 created "2016-06-24" @default.
- W301285140 creator A5030642434 @default.
- W301285140 creator A5052146722 @default.
- W301285140 date "1994-09-01" @default.
- W301285140 modified "2023-09-24" @default.
- W301285140 title "Linkage disequilibrium in the insulin gene region: Size variation at the 5{prime} flanking polymorphism and bimodality among {open_quotes}Class I{close_quotes} alleles" @default.
- W301285140 hasPublicationYear "1994" @default.
- W301285140 type Work @default.
- W301285140 sameAs 301285140 @default.
- W301285140 citedByCount "0" @default.
- W301285140 crossrefType "journal-article" @default.
- W301285140 hasAuthorship W301285140A5030642434 @default.
- W301285140 hasAuthorship W301285140A5052146722 @default.
- W301285140 hasConcept C104317684 @default.
- W301285140 hasConcept C135763542 @default.
- W301285140 hasConcept C168007829 @default.
- W301285140 hasConcept C180754005 @default.
- W301285140 hasConcept C197754878 @default.
- W301285140 hasConcept C35605836 @default.
- W301285140 hasConcept C54355233 @default.
- W301285140 hasConcept C86803240 @default.
- W301285140 hasConceptScore W301285140C104317684 @default.
- W301285140 hasConceptScore W301285140C135763542 @default.
- W301285140 hasConceptScore W301285140C168007829 @default.
- W301285140 hasConceptScore W301285140C180754005 @default.
- W301285140 hasConceptScore W301285140C197754878 @default.
- W301285140 hasConceptScore W301285140C35605836 @default.
- W301285140 hasConceptScore W301285140C54355233 @default.
- W301285140 hasConceptScore W301285140C86803240 @default.
- W301285140 hasIssue "3" @default.
- W301285140 hasLocation W3012851401 @default.
- W301285140 hasOpenAccess W301285140 @default.
- W301285140 hasPrimaryLocation W3012851401 @default.
- W301285140 hasRelatedWork W127700499 @default.
- W301285140 hasRelatedWork W1964071098 @default.
- W301285140 hasRelatedWork W1975246522 @default.
- W301285140 hasRelatedWork W1975307766 @default.
- W301285140 hasRelatedWork W1988803485 @default.
- W301285140 hasRelatedWork W1995976530 @default.
- W301285140 hasRelatedWork W1998408924 @default.
- W301285140 hasRelatedWork W2005509217 @default.
- W301285140 hasRelatedWork W2038996657 @default.
- W301285140 hasRelatedWork W2041148116 @default.
- W301285140 hasRelatedWork W2050501127 @default.
- W301285140 hasRelatedWork W2078842835 @default.
- W301285140 hasRelatedWork W2095083180 @default.
- W301285140 hasRelatedWork W2122505319 @default.
- W301285140 hasRelatedWork W212254432 @default.
- W301285140 hasRelatedWork W222861653 @default.
- W301285140 hasRelatedWork W306655710 @default.
- W301285140 hasRelatedWork W70084737 @default.
- W301285140 hasRelatedWork W1660849904 @default.
- W301285140 hasRelatedWork W2471713895 @default.
- W301285140 hasVolume "55" @default.
- W301285140 isParatext "false" @default.
- W301285140 isRetracted "false" @default.
- W301285140 magId "301285140" @default.
- W301285140 workType "article" @default.