FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012863670> ?p ?o ?g. }

• W3012863670 abstract "Abstract Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia. Additionally, many authors found microglial activation in cases of schizophrenia due to inflammatory mechanisms related mostly to an increase of pro-inflammatory cytokines. In order to gain new insights into the pathophysiology of schizophrenia, it is important to incorporate the latest published evidence concerning inflammatory mechanisms and kynurenine metabolism. This systematic review aims to collect reliable recent findings within the last decade supporting such a theory. Methods A structured search of electronic databases was conducted for publications between 2008 and 2018 to identify eligible studies investigating patients with schizophrenia/psychosis and the relationship between inflammation and kynurenine pathway. Applicable studies were systematically scored using the NIH Quality Assessment Tools. Two researchers independently extracted data on diagnosis (psychosis/schizophrenia), inflammation, and kynurenine/tryptophan metabolites. Results Ten eligible articles were identified where seven studies assessed blood samples and three assessed cerebrospinal fluid in schizophrenic patients. Of these articles: Four investigated the relationship between immunoglobulins and the kynurenine pathway and found correlations between IgA-mediated responses and levels of tryptophan metabolites (i.e., kynurenine pathway). Five examined the correlation between cytokines and kynurenine metabolites where three showed a relationship between elevated IL-6, TNF-α concentrations, and the kynurenine pathway. Only one study discovered correlations between IL-8 and the kynurenine pathway. Two studies showed correlations with lower concentrations of IL-4 and the kynurenine pathway. Moreover, this systematic review did not find a significant correlation between CRP ( n = 1 study), IFN-γ ( n = 3 studies), and the kynurenine pathway in schizophrenia. Interpretation These results emphasize how different inflammatory markers can unbalance the tryptophan/kynurenine pathway in schizophrenia. Several tryptophan/kynurenine pathway metabolites are produced which can, in turn, underlie different psychotic and cognitive symptoms via neurotransmission modulation. However, due to heterogeneity and the shortage of eligible articles, they do not robustly converge to the same findings. Hence, we recommend further studies with larger sample sizes to elucidate the possible interactions between the various markers, their blood vs. CSF ratios, and their correlation with schizophrenia symptoms." @default.
• W3012863670 created "2020-03-27" @default.
• W3012863670 creator A5000245598 @default.
• W3012863670 creator A5001648943 @default.
• W3012863670 creator A5026610554 @default.
• W3012863670 creator A5057718747 @default.
• W3012863670 date "2020-02-15" @default.
• W3012863670 modified "2023-10-18" @default.
• W3012863670 title "Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review" @default.
• W3012863670 cites W1225620574 @default.
• W3012863670 cites W1547937746 @default.
• W3012863670 cites W1559088113 @default.
• W3012863670 cites W1565159003 @default.
• W3012863670 cites W1594281178 @default.
• W3012863670 cites W1598480899 @default.
• W3012863670 cites W1782672155 @default.
• W3012863670 cites W1862342608 @default.
• W3012863670 cites W1972595076 @default.
• W3012863670 cites W1972719386 @default.
• W3012863670 cites W1973172818 @default.
• W3012863670 cites W1982896592 @default.
• W3012863670 cites W1983052404 @default.
• W3012863670 cites W1990584622 @default.
• W3012863670 cites W1992396801 @default.
• W3012863670 cites W2007197518 @default.
• W3012863670 cites W2010473895 @default.
• W3012863670 cites W2020444377 @default.
• W3012863670 cites W2022949524 @default.
• W3012863670 cites W203709983 @default.
• W3012863670 cites W2042731928 @default.
• W3012863670 cites W2051189132 @default.
• W3012863670 cites W2053195641 @default.
• W3012863670 cites W2053806684 @default.
• W3012863670 cites W2056547365 @default.
• W3012863670 cites W2058834701 @default.
• W3012863670 cites W2058901621 @default.
• W3012863670 cites W2059996790 @default.
• W3012863670 cites W2060401427 @default.
• W3012863670 cites W2060415968 @default.
• W3012863670 cites W2062631099 @default.
• W3012863670 cites W2063393311 @default.
• W3012863670 cites W2068664197 @default.
• W3012863670 cites W2071116774 @default.
• W3012863670 cites W2073144071 @default.
• W3012863670 cites W2076249077 @default.
• W3012863670 cites W2078660110 @default.
• W3012863670 cites W2085301448 @default.
• W3012863670 cites W2086201559 @default.
• W3012863670 cites W2098234649 @default.
• W3012863670 cites W2107798391 @default.
• W3012863670 cites W2113458499 @default.
• W3012863670 cites W2124807171 @default.
• W3012863670 cites W2134716410 @default.
• W3012863670 cites W2138889905 @default.
• W3012863670 cites W2141645427 @default.
• W3012863670 cites W2154965665 @default.
• W3012863670 cites W2156098321 @default.
• W3012863670 cites W2171832535 @default.
• W3012863670 cites W2259912978 @default.
• W3012863670 cites W2272394544 @default.
• W3012863670 cites W2293634496 @default.
• W3012863670 cites W2326740560 @default.
• W3012863670 cites W2329541771 @default.
• W3012863670 cites W2332025197 @default.
• W3012863670 cites W2366733740 @default.
• W3012863670 cites W2396821322 @default.
• W3012863670 cites W2397045879 @default.
• W3012863670 cites W246286872 @default.
• W3012863670 cites W2467740769 @default.
• W3012863670 cites W2469117952 @default.
• W3012863670 cites W2517700447 @default.
• W3012863670 cites W2527134336 @default.
• W3012863670 cites W2536051569 @default.
• W3012863670 cites W2555439513 @default.
• W3012863670 cites W2579935110 @default.
• W3012863670 cites W2582903515 @default.
• W3012863670 cites W2586728661 @default.
• W3012863670 cites W2587374695 @default.
• W3012863670 cites W2591810884 @default.
• W3012863670 cites W2591858183 @default.
• W3012863670 cites W2595474555 @default.
• W3012863670 cites W2598027787 @default.
• W3012863670 cites W2605574980 @default.
• W3012863670 cites W2605754455 @default.
• W3012863670 cites W2611951655 @default.
• W3012863670 cites W2727224893 @default.
• W3012863670 cites W2750739320 @default.
• W3012863670 cites W2752634797 @default.
• W3012863670 cites W2767495066 @default.
• W3012863670 cites W2789527934 @default.
• W3012863670 cites W2794645689 @default.
• W3012863670 cites W2808861689 @default.
• W3012863670 cites W2811290140 @default.
• W3012863670 cites W2888647009 @default.
• W3012863670 cites W2898485275 @default.
• W3012863670 cites W2906287592 @default.
• W3012863670 cites W2972823082 @default.
• W3012863670 cites W3187426197 @default.
• W3012863670 cites W4234860686 @default.
• W3012863670 cites W4294215472 @default.

• next