Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012877483> ?p ?o ?g. }
- W3012877483 endingPage "2513" @default.
- W3012877483 startingPage "2503" @default.
- W3012877483 abstract "Abstract Macrophages are critical for the initiation and resolution of the inflammatory phase of wound healing. In diabetes, macrophages display a prolonged inflammatory phenotype preventing tissue repair. TLRs, particularly TLR4, have been shown to regulate myeloid-mediated inflammation in wounds. We examined macrophages isolated from wounds of patients afflicted with diabetes and healthy controls as well as a murine diabetic model demonstrating dynamic expression of TLR4 results in altered metabolic pathways in diabetic macrophages. Further, using a myeloid-specific mixed-lineage leukemia 1 (MLL1) knockout (Mll1f/fLyz2Cre+), we determined that MLL1 drives Tlr4 expression in diabetic macrophages by regulating levels of histone H3 lysine 4 trimethylation on the Tlr4 promoter. Mechanistically, MLL1-mediated epigenetic alterations influence diabetic macrophage responsiveness to TLR4 stimulation and inhibit tissue repair. Pharmacological inhibition of the TLR4 pathway using a small molecule inhibitor (TAK-242) as well as genetic depletion of either Tlr4 (Tlr4−/−) or myeloid-specific Tlr4 (Tlr4f/fLyz2Cre+) resulted in improved diabetic wound healing. These results define an important role for MLL1-mediated epigenetic regulation of TLR4 in pathologic diabetic wound repair and suggest a target for therapeutic manipulation." @default.
- W3012877483 created "2020-03-27" @default.
- W3012877483 creator A5005740942 @default.
- W3012877483 creator A5022084087 @default.
- W3012877483 creator A5031129495 @default.
- W3012877483 creator A5039223415 @default.
- W3012877483 creator A5042650458 @default.
- W3012877483 creator A5047001268 @default.
- W3012877483 creator A5054894697 @default.
- W3012877483 creator A5055512437 @default.
- W3012877483 creator A5058777700 @default.
- W3012877483 creator A5064350342 @default.
- W3012877483 creator A5067214725 @default.
- W3012877483 creator A5068637941 @default.
- W3012877483 creator A5074350192 @default.
- W3012877483 creator A5082187941 @default.
- W3012877483 creator A5083840044 @default.
- W3012877483 creator A5087116586 @default.
- W3012877483 creator A5089792593 @default.
- W3012877483 creator A5090323418 @default.
- W3012877483 creator A5091815767 @default.
- W3012877483 date "2020-05-01" @default.
- W3012877483 modified "2023-10-15" @default.
- W3012877483 title "Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair" @default.
- W3012877483 cites W145600754 @default.
- W3012877483 cites W1596824448 @default.
- W3012877483 cites W1817033456 @default.
- W3012877483 cites W1967064280 @default.
- W3012877483 cites W1969670934 @default.
- W3012877483 cites W1976010325 @default.
- W3012877483 cites W1980735247 @default.
- W3012877483 cites W1998871958 @default.
- W3012877483 cites W1999935208 @default.
- W3012877483 cites W2001609725 @default.
- W3012877483 cites W2013956403 @default.
- W3012877483 cites W2014410888 @default.
- W3012877483 cites W2034657761 @default.
- W3012877483 cites W2042336817 @default.
- W3012877483 cites W2044003590 @default.
- W3012877483 cites W2054969539 @default.
- W3012877483 cites W2062608631 @default.
- W3012877483 cites W2065145765 @default.
- W3012877483 cites W2068793888 @default.
- W3012877483 cites W2069611885 @default.
- W3012877483 cites W2071588926 @default.
- W3012877483 cites W2072520173 @default.
- W3012877483 cites W2076253786 @default.
- W3012877483 cites W2076272449 @default.
- W3012877483 cites W2080863876 @default.
- W3012877483 cites W2082867683 @default.
- W3012877483 cites W2087613739 @default.
- W3012877483 cites W2089532303 @default.
- W3012877483 cites W2089573422 @default.
- W3012877483 cites W2092386544 @default.
- W3012877483 cites W2096179876 @default.
- W3012877483 cites W2110231257 @default.
- W3012877483 cites W2120472250 @default.
- W3012877483 cites W2123212032 @default.
- W3012877483 cites W2128924195 @default.
- W3012877483 cites W2133449490 @default.
- W3012877483 cites W2133523105 @default.
- W3012877483 cites W2134897227 @default.
- W3012877483 cites W2136487005 @default.
- W3012877483 cites W2141118938 @default.
- W3012877483 cites W2143461874 @default.
- W3012877483 cites W2143809126 @default.
- W3012877483 cites W2156013098 @default.
- W3012877483 cites W2162434296 @default.
- W3012877483 cites W2164481653 @default.
- W3012877483 cites W2285157527 @default.
- W3012877483 cites W2301044272 @default.
- W3012877483 cites W2312537679 @default.
- W3012877483 cites W2516235556 @default.
- W3012877483 cites W2549987875 @default.
- W3012877483 cites W2587237321 @default.
- W3012877483 cites W2730667825 @default.
- W3012877483 cites W2738575309 @default.
- W3012877483 cites W2789287894 @default.
- W3012877483 cites W2799794258 @default.
- W3012877483 cites W2901765784 @default.
- W3012877483 cites W2912828968 @default.
- W3012877483 cites W2914298128 @default.
- W3012877483 cites W2953575557 @default.
- W3012877483 cites W2962755997 @default.
- W3012877483 cites W2962822924 @default.
- W3012877483 cites W2967091916 @default.
- W3012877483 cites W2991099207 @default.
- W3012877483 doi "https://doi.org/10.4049/jimmunol.1901263" @default.
- W3012877483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7443363" @default.
- W3012877483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32205424" @default.
- W3012877483 hasPublicationYear "2020" @default.
- W3012877483 type Work @default.
- W3012877483 sameAs 3012877483 @default.
- W3012877483 citedByCount "15" @default.
- W3012877483 countsByYear W30128774832020 @default.
- W3012877483 countsByYear W30128774832021 @default.
- W3012877483 countsByYear W30128774832022 @default.
- W3012877483 countsByYear W30128774832023 @default.