Matches in SemOpenAlex for { <https://semopenalex.org/work/W3012894460> ?p ?o ?g. }
- W3012894460 endingPage "736" @default.
- W3012894460 startingPage "727" @default.
- W3012894460 abstract "Abstract Increased amygdala responsiveness is the hallmark of fear and a characteristic across patients with anxiety disorders. The amygdala is embedded in a complex regulatory circuit. Multiple different mechanisms may elevate amygdala responsiveness and lead to the occurrence of an anxiety disorder. While top-down control by the prefrontal cortex (PFC) downregulates amygdala responses, the locus coeruleus (LC) drives up amygdala activation via noradrenergic projections. This indicates that the same fearful phenotype may result from different neural mechanisms. We propose a mechanistic model that defines three different neural biomarkers causing amygdala hyper-responsiveness in patients with anxiety disorders: (a) inherent amygdala hypersensitivity, (b) low prefrontal control and (c) high LC drive. First-line treatment for anxiety disorders is exposure-based cognitive behavioural therapy, which strengthens PFC recruitment during emotion regulation and thus targets low-prefrontal control. A treatment response rate around 50% (Loerinc et al., 2015, Clinical Psychological Reviews , 42 , 72–82) might indicate heterogeneity of underlying neurobiological mechanisms among patients, presumably leading to high variation in treatment benefit. Transforming insights from cognitive neuroscience into applicable clinical heuristics to categorise patients based on their underlying biomarker may support individualised treatment selection in psychiatry. We review literature on the three anxiety-related mechanisms and present a mechanistic model that may serve as a rational for pathology-based diagnostic and biomarker-guided treatment selection in psychiatry." @default.
- W3012894460 created "2020-03-27" @default.
- W3012894460 creator A5002412087 @default.
- W3012894460 creator A5062747951 @default.
- W3012894460 creator A5064429146 @default.
- W3012894460 creator A5083986039 @default.
- W3012894460 date "2020-03-24" @default.
- W3012894460 modified "2023-10-11" @default.
- W3012894460 title "A mechanistic model for individualised treatment of anxiety disorders based on predictive neural biomarkers" @default.
- W3012894460 cites W1160212399 @default.
- W3012894460 cites W1505486340 @default.
- W3012894460 cites W1513763202 @default.
- W3012894460 cites W1604468358 @default.
- W3012894460 cites W1897149844 @default.
- W3012894460 cites W1963525383 @default.
- W3012894460 cites W1967685853 @default.
- W3012894460 cites W1967996189 @default.
- W3012894460 cites W1987605932 @default.
- W3012894460 cites W1989982790 @default.
- W3012894460 cites W1990121190 @default.
- W3012894460 cites W1996860933 @default.
- W3012894460 cites W2001362807 @default.
- W3012894460 cites W2002360316 @default.
- W3012894460 cites W2004928159 @default.
- W3012894460 cites W2005809763 @default.
- W3012894460 cites W2007311340 @default.
- W3012894460 cites W2008123860 @default.
- W3012894460 cites W2008929007 @default.
- W3012894460 cites W2010522880 @default.
- W3012894460 cites W2012804469 @default.
- W3012894460 cites W2016117011 @default.
- W3012894460 cites W2018255469 @default.
- W3012894460 cites W2030325164 @default.
- W3012894460 cites W2039548603 @default.
- W3012894460 cites W2039840963 @default.
- W3012894460 cites W2043334105 @default.
- W3012894460 cites W2054511295 @default.
- W3012894460 cites W2055875395 @default.
- W3012894460 cites W2056249673 @default.
- W3012894460 cites W2058940618 @default.
- W3012894460 cites W2066525901 @default.
- W3012894460 cites W2068673705 @default.
- W3012894460 cites W2071256705 @default.
- W3012894460 cites W2076079223 @default.
- W3012894460 cites W2076445235 @default.
- W3012894460 cites W2078565912 @default.
- W3012894460 cites W2086354265 @default.
- W3012894460 cites W2086361121 @default.
- W3012894460 cites W2088242772 @default.
- W3012894460 cites W2088880330 @default.
- W3012894460 cites W2105144622 @default.
- W3012894460 cites W2109406833 @default.
- W3012894460 cites W2109682741 @default.
- W3012894460 cites W2110747672 @default.
- W3012894460 cites W2111968444 @default.
- W3012894460 cites W2113052000 @default.
- W3012894460 cites W2113080571 @default.
- W3012894460 cites W2113360349 @default.
- W3012894460 cites W2114242188 @default.
- W3012894460 cites W2114429947 @default.
- W3012894460 cites W2117104656 @default.
- W3012894460 cites W2123696958 @default.
- W3012894460 cites W2127310799 @default.
- W3012894460 cites W2128960262 @default.
- W3012894460 cites W2131314356 @default.
- W3012894460 cites W2134015193 @default.
- W3012894460 cites W2137811349 @default.
- W3012894460 cites W2138184969 @default.
- W3012894460 cites W2140566554 @default.
- W3012894460 cites W2148011447 @default.
- W3012894460 cites W2148716279 @default.
- W3012894460 cites W2149612743 @default.
- W3012894460 cites W2151345684 @default.
- W3012894460 cites W2151852296 @default.
- W3012894460 cites W2153734379 @default.
- W3012894460 cites W2157643754 @default.
- W3012894460 cites W2160844797 @default.
- W3012894460 cites W2161114075 @default.
- W3012894460 cites W2164348509 @default.
- W3012894460 cites W2166864184 @default.
- W3012894460 cites W2167540269 @default.
- W3012894460 cites W2170184275 @default.
- W3012894460 cites W2171662288 @default.
- W3012894460 cites W2346528861 @default.
- W3012894460 cites W2369104392 @default.
- W3012894460 cites W2469915283 @default.
- W3012894460 cites W2562873855 @default.
- W3012894460 cites W2563369338 @default.
- W3012894460 cites W2564300191 @default.
- W3012894460 cites W2577085700 @default.
- W3012894460 cites W2581558860 @default.
- W3012894460 cites W2600286291 @default.
- W3012894460 cites W2608783876 @default.
- W3012894460 cites W2613219306 @default.
- W3012894460 cites W2736579461 @default.
- W3012894460 cites W2739325771 @default.
- W3012894460 cites W2739995693 @default.
- W3012894460 cites W2763252886 @default.