FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013054503> ?p ?o ?g. }

• W3013054503 abstract "Immune checkpoint inhibition (ICI) of the PD-1/PD-L1 axis shows durable responses in a subset of patients with metastatic urothelial carcinoma (UC). However, PD-L1 expression in tumor biopsies does not necessarily correlate with response to PD-1/PD-L1 inhibitors. Thus, a reliable predictive biomarker is urgently needed. Here, the expression of PD-L1 on circulating tumor cells (CTCs) in blood from patients with advanced UC was analyzed. For this purpose, an assay to test PD-L1 expression on CTCs using the CellSearch® system was established using cells of five UC cell lines spiked into blood samples from healthy donors and applied to a heterogeneous cohort of UC patients. Enumeration of CTCs was performed in blood samples from 49 patients with advanced UC. PD-L1 expression in ≥1 CTC was found in 10 of 16 CTC-positive samples (63%). Both intra- and inter-patient heterogeneity regarding PD-L1 expression of CTCs were observed. Furthermore, vimentin-expressing CTCs were detected in 4 of 15 CTC-positive samples (27%), independently of PD-L1 analysis. Both CTC detection and presence of CTCs with moderate or strong PD-L1 expression correlated with worse overall survival. Analyses during disease course of three individual patients receiving ICI suggest that apart from CTC numbers also PD-L1 expression on CTCs might potentially indicate disease progression.This is the first study demonstrating the feasibility to detect CTC-PD-L1 expression in patients with advanced UC using the CellSearch® system. This assay is readily available for clinical application and could be implemented in future clinical trials to evaluate its relevance for predicting and monitoring response to ICI." @default.
• W3013054503 created "2020-04-03" @default.
• W3013054503 creator A5020661834 @default.
• W3013054503 creator A5032787230 @default.
• W3013054503 creator A5038268175 @default.
• W3013054503 creator A5038860123 @default.
• W3013054503 creator A5042492852 @default.
• W3013054503 creator A5048105827 @default.
• W3013054503 creator A5054877901 @default.
• W3013054503 creator A5065748857 @default.
• W3013054503 creator A5069034017 @default.
• W3013054503 creator A5074491780 @default.
• W3013054503 creator A5078288046 @default.
• W3013054503 creator A5091331058 @default.
• W3013054503 date "2020-01-01" @default.
• W3013054503 modified "2023-10-16" @default.
• W3013054503 title "Evaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC)" @default.
• W3013054503 cites W1909809324 @default.
• W3013054503 cites W1917588793 @default.
• W3013054503 cites W1959742401 @default.
• W3013054503 cites W1964081206 @default.
• W3013054503 cites W1972882573 @default.
• W3013054503 cites W1983093014 @default.
• W3013054503 cites W2002941602 @default.
• W3013054503 cites W2004939067 @default.
• W3013054503 cites W2022465587 @default.
• W3013054503 cites W2024783386 @default.
• W3013054503 cites W2034312385 @default.
• W3013054503 cites W2048452946 @default.
• W3013054503 cites W2076583198 @default.
• W3013054503 cites W2087641573 @default.
• W3013054503 cites W2119764457 @default.
• W3013054503 cites W2127046868 @default.
• W3013054503 cites W2161661776 @default.
• W3013054503 cites W2165246114 @default.
• W3013054503 cites W2167198989 @default.
• W3013054503 cites W2168428234 @default.
• W3013054503 cites W2173565120 @default.
• W3013054503 cites W2194796823 @default.
• W3013054503 cites W2220506303 @default.
• W3013054503 cites W2253000935 @default.
• W3013054503 cites W2261056101 @default.
• W3013054503 cites W2289256168 @default.
• W3013054503 cites W2338391827 @default.
• W3013054503 cites W2507710416 @default.
• W3013054503 cites W2516619560 @default.
• W3013054503 cites W2521381098 @default.
• W3013054503 cites W2522277066 @default.
• W3013054503 cites W2526691095 @default.
• W3013054503 cites W2557254423 @default.
• W3013054503 cites W2560018230 @default.
• W3013054503 cites W2584071843 @default.
• W3013054503 cites W2606331690 @default.
• W3013054503 cites W2612431515 @default.
• W3013054503 cites W2654616069 @default.
• W3013054503 cites W2729354727 @default.
• W3013054503 cites W2765385456 @default.
• W3013054503 cites W2767280760 @default.
• W3013054503 cites W2771637939 @default.
• W3013054503 cites W2773629709 @default.
• W3013054503 cites W2781147042 @default.
• W3013054503 cites W2810444162 @default.
• W3013054503 cites W2886055678 @default.
• W3013054503 cites W2950192777 @default.
• W3013054503 cites W4251731689 @default.
• W3013054503 cites W634312238 @default.
• W3013054503 doi "https://doi.org/10.1080/2162402x.2020.1738798" @default.
• W3013054503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7199812" @default.
• W3013054503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32391189" @default.
• W3013054503 hasPublicationYear "2020" @default.
• W3013054503 type Work @default.
• W3013054503 sameAs 3013054503 @default.
• W3013054503 citedByCount "29" @default.
• W3013054503 countsByYear W30130545032020 @default.
• W3013054503 countsByYear W30130545032021 @default.
• W3013054503 countsByYear W30130545032022 @default.
• W3013054503 countsByYear W30130545032023 @default.
• W3013054503 crossrefType "journal-article" @default.
• W3013054503 hasAuthorship W3013054503A5020661834 @default.
• W3013054503 hasAuthorship W3013054503A5032787230 @default.
• W3013054503 hasAuthorship W3013054503A5038268175 @default.
• W3013054503 hasAuthorship W3013054503A5038860123 @default.
• W3013054503 hasAuthorship W3013054503A5042492852 @default.
• W3013054503 hasAuthorship W3013054503A5048105827 @default.
• W3013054503 hasAuthorship W3013054503A5054877901 @default.
• W3013054503 hasAuthorship W3013054503A5065748857 @default.
• W3013054503 hasAuthorship W3013054503A5069034017 @default.
• W3013054503 hasAuthorship W3013054503A5074491780 @default.
• W3013054503 hasAuthorship W3013054503A5078288046 @default.
• W3013054503 hasAuthorship W3013054503A5091331058 @default.
• W3013054503 hasBestOaLocation W30130545031 @default.
• W3013054503 hasConcept C121608353 @default.
• W3013054503 hasConcept C126322002 @default.
• W3013054503 hasConcept C143998085 @default.
• W3013054503 hasConcept C2777701055 @default.
• W3013054503 hasConcept C2778822529 @default.
• W3013054503 hasConcept C2779013556 @default.
• W3013054503 hasConcept C2779134260 @default.
• W3013054503 hasConcept C2779529041 @default.
• W3013054503 hasConcept C2781053074 @default.

• next