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- W3013066730 endingPage "113925" @default.
- W3013066730 startingPage "113925" @default.
- W3013066730 abstract "Lipids and their mediators are known to play a pro-inflammatory role in several human diseases including asthma. The influence of leukotrienes and prostaglandins through arachidonate metabolism in asthma pathophysiology is well established and hence, prompted the way for therapeutic strategies targeting lipid metabolites. In addition, various types of fatty acids have been reported to play a diverse role in asthma. For instance, CD4+ T-lymphocytes differentiation towards T-effector (Teff) or T-regulatory (Tregs) cells seems to be controlled reciprocally by fatty acid metabolic pathways. Further, the dysregulated lipid status in obesity complicates the asthma manifestations suggesting the role of lipid metabolites particularly ω-6 fatty acids in the process. On the other hand, clinical and pre-clinical studies suggests the role of short chain fatty acids in curbing asthma through upregulation of T-regulatory cells or clearance of inflammatory cells through promoting apoptosis. Accordingly, the present review compiles various studies for comprehensive analysis of different types of lipid based metabolites in asthma manifestation. Finally, we have proposed certain strategies which may enhance the usefulness of lipid mediators for balanced immune response during asthma." @default.
- W3013066730 created "2020-04-03" @default.
- W3013066730 creator A5000633304 @default.
- W3013066730 creator A5045419638 @default.
- W3013066730 creator A5061706236 @default.
- W3013066730 creator A5080444742 @default.
- W3013066730 date "2020-09-01" @default.
- W3013066730 modified "2023-09-30" @default.
- W3013066730 title "Lipid mediators and asthma: Scope of therapeutics" @default.
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