Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013067042> ?p ?o ?g. }
- W3013067042 endingPage "183279" @default.
- W3013067042 startingPage "183279" @default.
- W3013067042 abstract "The functional and structural concept of tight junctions has developed after discovery of claudin and TAMP proteins. Many of these proteins contribute to epi- and endothelial barrier but some, in contrast, form paracellular channels. Claudins form the backbone of tight junction (TJ) strands whereas other proteins regulate TJ dynamics. The current joined double-row model of TJ strands and channels is crucially based on the linear alignment of claudin-15 in the crystal. Molecular dynamics simulations, protein docking, mutagenesis, cellular TJ reconstitution, and electron microscopy studies largely support stability and functionality of the model. Here, we summarize in silico and in vitro data about TJ strand assembly including comparison of claudin crystal structures and alternative models. Sequence comparisons, experimental and structural data substantiate differentiation of classic and non-classic claudins differing in motifs related to strand assembly. Classic claudins seem to share a similar mechanism of strand formation. Interface variations likely contribute to TJ strand flexibility. Combined in vitro/in silico studies are expected to elucidate mechanistic keys determining TJ regulation." @default.
- W3013067042 created "2020-04-03" @default.
- W3013067042 creator A5006670791 @default.
- W3013067042 creator A5023308750 @default.
- W3013067042 creator A5042226695 @default.
- W3013067042 creator A5081013332 @default.
- W3013067042 creator A5089794891 @default.
- W3013067042 date "2020-07-01" @default.
- W3013067042 modified "2023-10-17" @default.
- W3013067042 title "Molecular architecture and assembly of the tight junction backbone" @default.
- W3013067042 cites W1166092225 @default.
- W3013067042 cites W1498982214 @default.
- W3013067042 cites W1877998438 @default.
- W3013067042 cites W1916793731 @default.
- W3013067042 cites W1967597984 @default.
- W3013067042 cites W1968898370 @default.
- W3013067042 cites W1969012119 @default.
- W3013067042 cites W1970698118 @default.
- W3013067042 cites W1973039531 @default.
- W3013067042 cites W1976116333 @default.
- W3013067042 cites W1979207410 @default.
- W3013067042 cites W1981760537 @default.
- W3013067042 cites W1981819658 @default.
- W3013067042 cites W1988301438 @default.
- W3013067042 cites W1992369970 @default.
- W3013067042 cites W1994837626 @default.
- W3013067042 cites W1998372028 @default.
- W3013067042 cites W1998461769 @default.
- W3013067042 cites W1999294993 @default.
- W3013067042 cites W2000422049 @default.
- W3013067042 cites W2000580750 @default.
- W3013067042 cites W2006698894 @default.
- W3013067042 cites W2006965597 @default.
- W3013067042 cites W2010375822 @default.
- W3013067042 cites W2010641543 @default.
- W3013067042 cites W2011356699 @default.
- W3013067042 cites W2014073692 @default.
- W3013067042 cites W2014516706 @default.
- W3013067042 cites W2022219701 @default.
- W3013067042 cites W2024005495 @default.
- W3013067042 cites W2027005863 @default.
- W3013067042 cites W2028224423 @default.
- W3013067042 cites W2031888318 @default.
- W3013067042 cites W2035728698 @default.
- W3013067042 cites W2037479315 @default.
- W3013067042 cites W2040645020 @default.
- W3013067042 cites W2045084108 @default.
- W3013067042 cites W2050174110 @default.
- W3013067042 cites W2052581328 @default.
- W3013067042 cites W2061955387 @default.
- W3013067042 cites W2066744554 @default.
- W3013067042 cites W2067551508 @default.
- W3013067042 cites W2072108209 @default.
- W3013067042 cites W2074578509 @default.
- W3013067042 cites W2075468859 @default.
- W3013067042 cites W2075536490 @default.
- W3013067042 cites W2077716755 @default.
- W3013067042 cites W2078437499 @default.
- W3013067042 cites W2079147888 @default.
- W3013067042 cites W2079482620 @default.
- W3013067042 cites W2080069132 @default.
- W3013067042 cites W2082609680 @default.
- W3013067042 cites W2087710101 @default.
- W3013067042 cites W2088056047 @default.
- W3013067042 cites W2088892772 @default.
- W3013067042 cites W2094468216 @default.
- W3013067042 cites W2100483442 @default.
- W3013067042 cites W2101937063 @default.
- W3013067042 cites W2102015799 @default.
- W3013067042 cites W2103704800 @default.
- W3013067042 cites W2103729492 @default.
- W3013067042 cites W2103831817 @default.
- W3013067042 cites W2106203228 @default.
- W3013067042 cites W2107336169 @default.
- W3013067042 cites W2120914031 @default.
- W3013067042 cites W2123230988 @default.
- W3013067042 cites W2124517680 @default.
- W3013067042 cites W2130599353 @default.
- W3013067042 cites W2144272339 @default.
- W3013067042 cites W2147810729 @default.
- W3013067042 cites W2147977611 @default.
- W3013067042 cites W2149037769 @default.
- W3013067042 cites W2149199388 @default.
- W3013067042 cites W2154019529 @default.
- W3013067042 cites W2156773809 @default.
- W3013067042 cites W2159980792 @default.
- W3013067042 cites W2160753648 @default.
- W3013067042 cites W2163830368 @default.
- W3013067042 cites W2168568712 @default.
- W3013067042 cites W2175214952 @default.
- W3013067042 cites W2218904293 @default.
- W3013067042 cites W2223893340 @default.
- W3013067042 cites W2235911675 @default.
- W3013067042 cites W2316646352 @default.
- W3013067042 cites W2330758825 @default.
- W3013067042 cites W2338240784 @default.
- W3013067042 cites W2340317540 @default.
- W3013067042 cites W2474758439 @default.