FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013087348> ?p ?o ?g. }

• W3013087348 endingPage "828" @default.
• W3013087348 startingPage "828" @default.
• W3013087348 abstract "The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylation status (by methylation-specific polymerase chain reaction (MS-PCR) and MassARRAY® assays), and BRCA1 protein expression using immunohistochemistry (IHC), and their clinicopathological significance in 248 chemotherapy-naïve TNBC samples. Fifty-five tumors (22%) exhibited BRCA1 promoter hypermethylation, with a high concordance rate between MS-PCR and MassARRAY® results. Promoter hypermethylation was associated with reduced IHC BRCA1 protein expression (p = 0.005), and expression of Programmed death-ligand 1 protein (PD-L1) by tumor and immune cells (p = 0.03 and 0.011, respectively). A trend was found between promoter hypermethylation and basal marker staining (p = 0.058), and between BRCA1 expression and a basal-like phenotype. In multivariate analysis, relapse-free survival was significantly associated with N stage, adjuvant chemotherapy, and histological subtype. Overall survival was significantly associated with T and N stage, histology, and adjuvant chemotherapy. In addition, patients with tumors harboring BRCA1 promoter hypermethylation derived the most benefit from adjuvant chemotherapy. In conclusion, BRCA1 promoter hypermethylation is associated with TNBC sensitivity to adjuvant chemotherapy, basal-like features and PD-L1 expression. BRCA1 IHC expression is not a good surrogate marker for promoter hypermethylation and is not independently associated with prognosis. Association between promoter hypermethylation and sensitivity to Poly(ADP-ribose) polymerase PARP inhibitors needs to be evaluated in a specific series of patients." @default.
• W3013087348 created "2020-04-03" @default.
• W3013087348 creator A5004904819 @default.
• W3013087348 creator A5006581775 @default.
• W3013087348 creator A5007996044 @default.
• W3013087348 creator A5019839327 @default.
• W3013087348 creator A5020364190 @default.
• W3013087348 creator A5026447642 @default.
• W3013087348 creator A5031089086 @default.
• W3013087348 creator A5035249331 @default.
• W3013087348 creator A5047252823 @default.
• W3013087348 creator A5053668514 @default.
• W3013087348 creator A5073780219 @default.
• W3013087348 creator A5087747021 @default.
• W3013087348 date "2020-03-30" @default.
• W3013087348 modified "2023-10-18" @default.
• W3013087348 title "BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer" @default.
• W3013087348 cites W1523531555 @default.
• W3013087348 cites W1869304578 @default.
• W3013087348 cites W1915035420 @default.
• W3013087348 cites W1976385056 @default.
• W3013087348 cites W1984566339 @default.
• W3013087348 cites W1995036570 @default.
• W3013087348 cites W1998257195 @default.
• W3013087348 cites W2000197817 @default.
• W3013087348 cites W2012262218 @default.
• W3013087348 cites W2025438332 @default.
• W3013087348 cites W2029561999 @default.
• W3013087348 cites W2034563413 @default.
• W3013087348 cites W2038419615 @default.
• W3013087348 cites W2040587605 @default.
• W3013087348 cites W2044702943 @default.
• W3013087348 cites W2047708686 @default.
• W3013087348 cites W2050070476 @default.
• W3013087348 cites W2053355903 @default.
• W3013087348 cites W2062856589 @default.
• W3013087348 cites W2073025417 @default.
• W3013087348 cites W2076106771 @default.
• W3013087348 cites W2080715065 @default.
• W3013087348 cites W2084844247 @default.
• W3013087348 cites W2097002056 @default.
• W3013087348 cites W2097255042 @default.
• W3013087348 cites W2100413206 @default.
• W3013087348 cites W2100766868 @default.
• W3013087348 cites W2102596641 @default.
• W3013087348 cites W2105567212 @default.
• W3013087348 cites W2107089026 @default.
• W3013087348 cites W2108246461 @default.
• W3013087348 cites W2110017381 @default.
• W3013087348 cites W2114416638 @default.
• W3013087348 cites W2117964602 @default.
• W3013087348 cites W2119311466 @default.
• W3013087348 cites W2122205071 @default.
• W3013087348 cites W2123129045 @default.
• W3013087348 cites W2123696077 @default.
• W3013087348 cites W2131994307 @default.
• W3013087348 cites W2133296095 @default.
• W3013087348 cites W2135953007 @default.
• W3013087348 cites W2141160141 @default.
• W3013087348 cites W2141702105 @default.
• W3013087348 cites W2142491513 @default.
• W3013087348 cites W2143291249 @default.
• W3013087348 cites W2144351239 @default.
• W3013087348 cites W2148027217 @default.
• W3013087348 cites W2149160061 @default.
• W3013087348 cites W2150133682 @default.
• W3013087348 cites W2153206149 @default.
• W3013087348 cites W2154274541 @default.
• W3013087348 cites W2156010403 @default.
• W3013087348 cites W2157027870 @default.
• W3013087348 cites W2157285286 @default.
• W3013087348 cites W2157425241 @default.
• W3013087348 cites W2160234594 @default.
• W3013087348 cites W2168409298 @default.
• W3013087348 cites W2170602872 @default.
• W3013087348 cites W2170719826 @default.
• W3013087348 cites W2259802687 @default.
• W3013087348 cites W2289532611 @default.
• W3013087348 cites W2318661344 @default.
• W3013087348 cites W2339353396 @default.
• W3013087348 cites W2431433670 @default.
• W3013087348 cites W2463504782 @default.
• W3013087348 cites W2560367415 @default.
• W3013087348 cites W2621271973 @default.
• W3013087348 cites W2731374555 @default.
• W3013087348 cites W2779221466 @default.
• W3013087348 cites W2801956643 @default.
• W3013087348 cites W2806878953 @default.
• W3013087348 cites W2886168517 @default.
• W3013087348 cites W2886477543 @default.
• W3013087348 cites W2892170876 @default.
• W3013087348 cites W2892812402 @default.
• W3013087348 cites W2897422388 @default.
• W3013087348 cites W2978713168 @default.
• W3013087348 cites W2981966051 @default.
• W3013087348 cites W3093265161 @default.
• W3013087348 cites W4231797099 @default.
• W3013087348 cites W657132667 @default.

• next