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• W3013089541 abstract "Abstract Androgen is essential for male development and cortisol is involved in reproduction in fishes. However, the in vivo roles of cortisol and specific androgens such as 11-ketotestosterone (11-KT) in reproductive development need to be described with genetic models. Zebrafish cyp11c1 encodes 11β-hydroxylase, which is essential for the biosynthesis of 11-KT and cortisol. In this study, we generated a zebrafish mutant of cyp11c1 (cyp11c1-/-) and utilized it to clarify the roles of 11-KT and cortisol in sexual development and reproduction. The cyp11c1-/- fish had smaller genital papilla and exhibited defective natural mating but possessed mature gametes and were found at a sex ratio comparable to the wildtype control. The cyp11c1-/- males showed delayed and prolonged juvenile ovary-to-testis transition and displayed defective spermatogenesis at adult stage, which could be rescued by treatment with 11-ketoandrostenedione (11-KA) at certain stages. Specifically, during testis development of cyp11c1-/- males, the expression of insl3, cyp17a1, and amh was significantly decreased, suggesting that 11-KT is essential for the development and function of Leydig cells and Sertoli cells. Further, spermatogenesis-related dmrt1 was subsequently downregulated, leading to insufficient spermatogenesis. The cyp11c1-/- females showed a reduction in egg spawning and a failure of in vitro germinal vesicle breakdown, which could be partially rescued by cortisol treatment. Taken together, our study reveals that zebrafish Cyp11c1 is not required for definite sex differentiation but is essential for juvenile ovary-to-testis transition, Leydig cell development, and spermatogenesis in males through 11-KT, and it is also involved in oocyte maturation and ovulation in females through cortisol." @default.
• W3013089541 created "2020-04-03" @default.
• W3013089541 creator A5012545604 @default.
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• W3013089541 creator A5058040690 @default.
• W3013089541 date "2020-03-28" @default.
• W3013089541 modified "2023-10-16" @default.
• W3013089541 title "Zebrafish <i>cyp11c1</i> Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction" @default.
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• W3013089541 cites W1556189189 @default.
• W3013089541 cites W1662555992 @default.
• W3013089541 cites W1895530899 @default.
• W3013089541 cites W1915704240 @default.
• W3013089541 cites W1965799162 @default.
• W3013089541 cites W1969374493 @default.
• W3013089541 cites W1978702490 @default.
• W3013089541 cites W1978723581 @default.
• W3013089541 cites W1982999142 @default.
• W3013089541 cites W1992092121 @default.
• W3013089541 cites W1998863971 @default.
• W3013089541 cites W2001497035 @default.
• W3013089541 cites W2004469122 @default.
• W3013089541 cites W2005195078 @default.
• W3013089541 cites W2006555539 @default.
• W3013089541 cites W2007414972 @default.
• W3013089541 cites W2008053811 @default.
• W3013089541 cites W2011791666 @default.
• W3013089541 cites W2014834979 @default.
• W3013089541 cites W2018618597 @default.
• W3013089541 cites W2029552542 @default.
• W3013089541 cites W2030676023 @default.
• W3013089541 cites W2033943682 @default.
• W3013089541 cites W2041114367 @default.
• W3013089541 cites W2041316920 @default.
• W3013089541 cites W2041571596 @default.
• W3013089541 cites W2052160943 @default.
• W3013089541 cites W2053188090 @default.
• W3013089541 cites W2054070560 @default.
• W3013089541 cites W2061090674 @default.
• W3013089541 cites W2062003019 @default.
• W3013089541 cites W2079673371 @default.
• W3013089541 cites W2083937199 @default.
• W3013089541 cites W2085063786 @default.
• W3013089541 cites W2087175242 @default.
• W3013089541 cites W2096548531 @default.
• W3013089541 cites W2097686052 @default.
• W3013089541 cites W2107277218 @default.
• W3013089541 cites W2109971484 @default.
• W3013089541 cites W2110443113 @default.
• W3013089541 cites W2111369394 @default.
• W3013089541 cites W2113140808 @default.
• W3013089541 cites W2114346048 @default.
• W3013089541 cites W2119939362 @default.
• W3013089541 cites W2122097838 @default.
• W3013089541 cites W2124435804 @default.
• W3013089541 cites W2125349610 @default.
• W3013089541 cites W2125535253 @default.
• W3013089541 cites W2129307978 @default.
• W3013089541 cites W2132987101 @default.
• W3013089541 cites W2136061619 @default.
• W3013089541 cites W2137168087 @default.
• W3013089541 cites W2155730772 @default.
• W3013089541 cites W2159478160 @default.
• W3013089541 cites W2166542953 @default.
• W3013089541 cites W2166868764 @default.
• W3013089541 cites W2168420558 @default.
• W3013089541 cites W2170994125 @default.
• W3013089541 cites W2197381113 @default.
• W3013089541 cites W2232478231 @default.
• W3013089541 cites W2266093504 @default.
• W3013089541 cites W2414247940 @default.
• W3013089541 cites W2506462507 @default.
• W3013089541 cites W2521989110 @default.
• W3013089541 cites W2557043586 @default.
• W3013089541 cites W2560574425 @default.
• W3013089541 cites W2756230282 @default.
• W3013089541 cites W2771129185 @default.
• W3013089541 cites W2791395992 @default.
• W3013089541 cites W2889126360 @default.
• W3013089541 cites W2889674915 @default.
• W3013089541 cites W2892971962 @default.
• W3013089541 cites W2911722156 @default.
• W3013089541 cites W2951231225 @default.
• W3013089541 cites W2976660249 @default.
• W3013089541 cites W2999036336 @default.
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• W3013089541 doi "https://doi.org/10.1210/endocr/bqaa048" @default.
• W3013089541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32222764" @default.
• W3013089541 hasPublicationYear "2020" @default.
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