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• W3013093478 abstract "Abstract Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients’ sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2." @default.
• W3013093478 created "2020-04-03" @default.
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• W3013093478 date "2020-03-27" @default.
• W3013093478 modified "2023-10-18" @default.
• W3013093478 title "Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV" @default.
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• W3013093478 doi "https://doi.org/10.1038/s41467-020-15562-9" @default.
• W3013093478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7100515" @default.
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• W3013093478 hasPublicationYear "2020" @default.
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