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- W3013136169 abstract "Abstract Noxious mechanical information is transmitted through molecularly distinct nociceptors, with pinprick-evoked sharp sensitivity via A-fiber nociceptors marked by developmental expression of the neuropeptide Y receptor 2 (Npy2r) and von Frey filament-evoked punctate pressure information via unmyelinated C fiber nociceptors marked by MrgprD. However, the molecular programs controlling their development are only beginning to be understood. Here we demonstrate that Npy2r-expressing sensory neurons are in fact divided into two groups, based on transient or persistent Npy2r expression. Npy2r-transient neurons are myelinated, likely including A-fiber nociceptors, whereas Npy2r-persistent ones belong to unmyelinated pruriceptors that co-express Nppb. We then showed that the transcription factors NFIA and Runx1 are necessary for the development of Npy2r-transient A-fiber nociceptors and MrgprD + C-fiber nociceptors, respectively. Behaviorally, mice with conditional knockout of Nfia , but not Runx1 showed a marked attenuation of pinprick-evoked nocifensive responses. Our studies therefore identify a transcription factor controlling the development of myelinated nociceptors." @default.
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- W3013136169 date "2020-03-28" @default.
- W3013136169 modified "2023-09-28" @default.
- W3013136169 title "Nuclear Factor I/A Controls A-fiber Nociceptor Development" @default.
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- W3013136169 doi "https://doi.org/10.1007/s12264-020-00486-7" @default.
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