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- W3013150558 abstract "Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that intravenously injected carbon quantum dots, functionalized with multiple paired α-carboxyl and amino groups that bind to the large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs through π–π stacking interactions, enabled—in the absence of detectable toxicity—near-infrared fluorescence and photoacoustic imaging of the tumours and a reduction in tumour burden after the targeted delivery of chemotherapeutics to the tumours. The versatility of functionalization and high tumour selectivity of the quantum dots make them broadly suitable for tumour-specific imaging and drug delivery. Intravenously injected functionalized carbon quantum dots that bind to the large neutral amino acid transporter 1 and that structurally mimic large amino acids selectively accumulate in human tumours in mice, facilitating targeted theranostics." @default.
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- W3013150558 date "2020-03-30" @default.
- W3013150558 modified "2023-10-15" @default.
- W3013150558 title "Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids" @default.
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- W3013150558 doi "https://doi.org/10.1038/s41551-020-0540-y" @default.
- W3013150558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7197249" @default.
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- W3013150558 hasPublicationYear "2020" @default.
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