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• W3013172794 startingPage "e0230870" @default.
• W3013172794 abstract "When herpes simplex virus 1 (HSV-1) infection is initiated in the ocular, nasal, or oral cavity, sensory neurons within trigeminal ganglia (TG) become infected. Following a burst of viral transcription in TG neurons, lytic cycle viral genes are suppressed and latency is established. The latency-associated transcript (LAT) is the only viral gene abundantly expressed during latency, and LAT expression is important for the latency-reactivation cycle. Reactivation from latency is required for virus transmission and recurrent disease, including encephalitis. The Wnt/β-catenin signaling pathway is differentially expressed in TG during the bovine herpesvirus 1 latency-reactivation cycle. Hence, we hypothesized HSV-1 regulates the Wnt/β-catenin pathway and promotes maintenance of latency because this pathway enhances neuronal survival and axonal repair. New studies revealed β-catenin was expressed in significantly more TG neurons during latency compared to TG from uninfected mice or mice latently infected with a LAT-/- mutant virus. When TG explants were incubated with media containing dexamethasone to stimulate reactivation, significantly fewer β-catenin+ TG neurons were detected. Conversely, TG explants from uninfected mice or mice latently infected with a LAT-/- mutant increased the number of β-catenin+ TG neurons in the presence of DEX relative to samples not treated with DEX. Impairing Wnt signaling with small molecule antagonists reduced virus shedding during explant-induced reactivation. These studies suggested β-catenin was differentially expressed during the latency-reactivation cycle, in part due to LAT expression." @default.
• W3013172794 created "2020-04-03" @default.
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• W3013172794 date "2020-03-30" @default.
• W3013172794 modified "2023-10-17" @default.
• W3013172794 title "Herpes simplex virus 1 regulates β-catenin expression in TG neurons during the latency-reactivation cycle" @default.
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• W3013172794 doi "https://doi.org/10.1371/journal.pone.0230870" @default.
• W3013172794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7105109" @default.
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