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- W3013204233 abstract "Aim: To support pharmacokinetic studies and therapeutic monitoring of darunavir (DRV), a highly sensitive ELISA was developed for the determination of DRV in plasma samples at picogram levels. Results: The assay LOD and LOQ were 15 and 30 pg ml -1 , respectively. The working range of the assay was 20–2000 pg ml -1 . Analytical recoveries of DRV from spiked plasma were in the ranges of 98.4–113.0 and 86.0–99.1% for intra-assay and inter-assay runs, respectively. The precision of the assay was satisfactory. Conclusion: The ELISA is characterized by high throughput and it is expected to significantly contribute to routine analysis of DRV in its pharmacokinetic studies and therapeutic monitoring." @default.
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- W3013204233 date "2020-03-01" @default.
- W3013204233 modified "2023-10-16" @default.
- W3013204233 title "Development of a highly sensitive ELISA for determination of darunavir in plasma samples using a polyclonal antibody with high affinity and specificity" @default.
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- W3013204233 doi "https://doi.org/10.4155/bio-2020-0034" @default.
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