FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013232123> ?p ?o ?g. }

• W3013232123 endingPage "690.e5" @default.
• W3013232123 startingPage "676" @default.
• W3013232123 abstract "PurposeIntrathecal dexmedetomidine (DEX) has been used to improve the quality and duration of spinal anesthesia. The aim of this meta-analysis is to evaluate whether intrathecal DEX could prolong the duration of sensory and motor block during spinal anesthesia.MethodsWe searched PubMed, EMBASE, Web of Science, and the Cochrane Library for randomized controlled trials that investigated the facilitatory effects of intrathecal administration of DEX compared with those of a placebo on spinal anesthesia from inception to April 2019. Sensory and motor block durations, sensory and motor block onset times, time to first analgesic request, and DEX-related adverse effects were evaluated. Results were combined using fixed-effects or random effects modeling when appropriate.FindingsA total of 1478 patients from 25 clinical studies were included in the analysis. Compared with placebo, intrathecal DEX significantly prolonged the durations of both sensory block (weighted mean difference [WMD] = 134.42 min; 95% CI, 109.71–159.13 min; P < 0.001) and motor block (WMD = 114.27 min; 95% CI, 93.18–135.35 min; P < 0.001). It also hastened the onset of sensory block (WMD = −0.80 min; 95% CI, −1.21 to −0.40; P < 0.001) and motor block (WMD = −1.03 min; 95% CI, −1.51 to −0.56 min; P < 0.001). Furthermore, it delayed the time to first analgesic request (WMD = 216.90 min; 95% CI, 178.90–254.90 min; P < 0.001) and reduced the incidence of shivering (risk ratio [RR] = 0.39; 95% CI, 0.27–0.55; P < 0.001). DEX was associated with increased risk of transient bradycardia (RR = 1.59; 95% CI, 1.07–2.37; P = 0.022) and hypotension (RR = 1.40; 95% CI, 1.04–1.89; P = 0.026) but did not increase the incidence of postoperative nausea and vomiting (RR = 0.87; 95% CI, 0.62–1.24; P = 0.45).ImplicationsIntrathecal DEX can prolong the duration of sensory block, the duration of motor block, and the time to first analgesic request associated with spinal anesthesia." @default.
• W3013232123 created "2020-04-03" @default.
• W3013232123 creator A5007659639 @default.
• W3013232123 creator A5038073825 @default.
• W3013232123 creator A5042673928 @default.
• W3013232123 creator A5049186569 @default.
• W3013232123 creator A5050588614 @default.
• W3013232123 creator A5064072874 @default.
• W3013232123 creator A5082042877 @default.
• W3013232123 creator A5084685500 @default.
• W3013232123 creator A5088670866 @default.
• W3013232123 date "2020-04-01" @default.
• W3013232123 modified "2023-10-17" @default.
• W3013232123 title "Effect of 5-μg Dose of Dexmedetomidine in Combination With Intrathecal Bupivacaine on Spinal Anesthesia: A Systematic Review and Meta-analysis" @default.
• W3013232123 cites W1505219599 @default.
• W3013232123 cites W1532906040 @default.
• W3013232123 cites W1994114760 @default.
• W3013232123 cites W1994185487 @default.
• W3013232123 cites W2014274247 @default.
• W3013232123 cites W2014489798 @default.
• W3013232123 cites W2035894685 @default.
• W3013232123 cites W2036740 @default.
• W3013232123 cites W2049139712 @default.
• W3013232123 cites W2051152599 @default.
• W3013232123 cites W2067886800 @default.
• W3013232123 cites W2074934231 @default.
• W3013232123 cites W2080332266 @default.
• W3013232123 cites W2098923148 @default.
• W3013232123 cites W2100223992 @default.
• W3013232123 cites W2108980610 @default.
• W3013232123 cites W2112970335 @default.
• W3013232123 cites W2120539545 @default.
• W3013232123 cites W2133511912 @default.
• W3013232123 cites W2136119489 @default.
• W3013232123 cites W2150849842 @default.
• W3013232123 cites W2161374186 @default.
• W3013232123 cites W2161701454 @default.
• W3013232123 cites W2211885679 @default.
• W3013232123 cites W2266345636 @default.
• W3013232123 cites W2358944050 @default.
• W3013232123 cites W2463821864 @default.
• W3013232123 cites W2581812449 @default.
• W3013232123 cites W2585301918 @default.
• W3013232123 cites W2588541278 @default.
• W3013232123 cites W2604487146 @default.
• W3013232123 cites W2616453556 @default.
• W3013232123 cites W2734080496 @default.
• W3013232123 cites W2767172465 @default.
• W3013232123 cites W2790200512 @default.
• W3013232123 cites W2792130918 @default.
• W3013232123 cites W2806048849 @default.
• W3013232123 cites W2898921606 @default.
• W3013232123 cites W3142130703 @default.
• W3013232123 doi "https://doi.org/10.1016/j.clinthera.2020.02.009" @default.
• W3013232123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32222361" @default.
• W3013232123 hasPublicationYear "2020" @default.
• W3013232123 type Work @default.
• W3013232123 sameAs 3013232123 @default.
• W3013232123 citedByCount "8" @default.
• W3013232123 countsByYear W30132321232020 @default.
• W3013232123 countsByYear W30132321232021 @default.
• W3013232123 countsByYear W30132321232022 @default.
• W3013232123 countsByYear W30132321232023 @default.
• W3013232123 crossrefType "journal-article" @default.
• W3013232123 hasAuthorship W3013232123A5007659639 @default.
• W3013232123 hasAuthorship W3013232123A5038073825 @default.
• W3013232123 hasAuthorship W3013232123A5042673928 @default.
• W3013232123 hasAuthorship W3013232123A5049186569 @default.
• W3013232123 hasAuthorship W3013232123A5050588614 @default.
• W3013232123 hasAuthorship W3013232123A5064072874 @default.
• W3013232123 hasAuthorship W3013232123A5082042877 @default.
• W3013232123 hasAuthorship W3013232123A5084685500 @default.
• W3013232123 hasAuthorship W3013232123A5088670866 @default.
• W3013232123 hasBestOaLocation W30132321231 @default.
• W3013232123 hasConcept C120665830 @default.
• W3013232123 hasConcept C121332964 @default.
• W3013232123 hasConcept C126322002 @default.
• W3013232123 hasConcept C141071460 @default.
• W3013232123 hasConcept C142724271 @default.
• W3013232123 hasConcept C157820659 @default.
• W3013232123 hasConcept C168563851 @default.
• W3013232123 hasConcept C197934379 @default.
• W3013232123 hasConcept C204787440 @default.
• W3013232123 hasConcept C27081682 @default.
• W3013232123 hasConcept C2776814716 @default.
• W3013232123 hasConcept C2780820201 @default.
• W3013232123 hasConcept C2781258859 @default.
• W3013232123 hasConcept C2781302539 @default.
• W3013232123 hasConcept C2781328992 @default.
• W3013232123 hasConcept C2992886682 @default.
• W3013232123 hasConcept C42219234 @default.
• W3013232123 hasConcept C61511704 @default.
• W3013232123 hasConcept C71924100 @default.
• W3013232123 hasConcept C95190672 @default.
• W3013232123 hasConceptScore W3013232123C120665830 @default.
• W3013232123 hasConceptScore W3013232123C121332964 @default.
• W3013232123 hasConceptScore W3013232123C126322002 @default.
• W3013232123 hasConceptScore W3013232123C141071460 @default.

• next