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- W3013343359 abstract "In this work, 1,4-dioxane-mediated hydroxylhydrative aza-cyclization of 2-alkynylbenzamide is developed for the synthesis of 3-hydroxylisoindolin-1-ones. The transformation proceeds smoothly in water with good yields and a broad reaction scope. Mechanistic studies show that regioselective brimonative 5-exo-dig aza-cyclization, bromohydration of the resulting alkene groups, and hydrolysis of dibromo compounds are involved. Compared to the traditional methodologies, the synthetic procedure reported herein represents a cleaner route toward 3-hydroxylisoindolin-1-ones." @default.
- W3013343359 created "2020-04-03" @default.
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- W3013343359 date "2020-03-31" @default.
- W3013343359 modified "2023-10-18" @default.
- W3013343359 title "Synthesis of 3-Hydroxyisoindolin-1-ones through 1,4-Dioxane-Mediated Hydroxylhydrative aza-Cyclization of 2-Alkynylbenzamide in Water" @default.
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- W3013343359 doi "https://doi.org/10.1021/acs.joc.9b03466" @default.
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