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- W3013346247 endingPage "101770" @default.
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- W3013346247 abstract "Embryonic neural stem cells (NSCs), comprising neuroepithelial and radial glial cells, are indispensable precursors of neurons and glia in the mammalian developing brain. Since the process of neurogenesis occurs in a hypoxic environment, the question arises of how NSCs deal with low oxygen tension and whether it affects their stemness. Genes from the hypoxia-inducible factors (HIF) family are well known factors governing cellular response to hypoxic conditions. In this study, we have discovered that the endogenous stabilization of hypoxia-inducible factor 1α (Hif1α) during neural induction is critical for the normal development of the NSCs pool by preventing its premature depletion and differentiation. The knock-out of the Hif1α gene in mESC-derived neurospheres led to a decrease in self-renewal of NSCs, paralleled by an increase in neuronal differentiation. Similarly, neuroepithelial cells differentiated in hypoxia exhibited accelerated neurogenesis soon after Hif1α knock-down. In both models, the loss of Hif1α was accompanied by an immediate drop in neural repressor Hes1 levels while changes in Notch signaling were not observed. We found that active Hif1α/Arnt1 transcription complex bound to the evolutionarily conserved site in Hes1 gene promoter in both neuroepithelial cells and neural tissue of E8.5 - 9.5 embryos. Taken together, these results emphasize the novel role of Hif1α in the regulation of early NSCs population through the activation of neural repressor Hes1, independently of Notch signaling." @default.
- W3013346247 created "2020-04-03" @default.
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- W3013346247 date "2020-05-01" @default.
- W3013346247 modified "2023-10-17" @default.
- W3013346247 title "Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1" @default.
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- W3013346247 cites W1906569886 @default.
- W3013346247 cites W1967929323 @default.
- W3013346247 cites W1968461724 @default.
- W3013346247 cites W1973289124 @default.
- W3013346247 cites W1973475852 @default.
- W3013346247 cites W1974372416 @default.
- W3013346247 cites W1977241226 @default.
- W3013346247 cites W1979179112 @default.
- W3013346247 cites W1984324225 @default.
- W3013346247 cites W1984604224 @default.
- W3013346247 cites W1987145582 @default.
- W3013346247 cites W1988976106 @default.
- W3013346247 cites W1989920563 @default.
- W3013346247 cites W1994859370 @default.
- W3013346247 cites W1995734429 @default.
- W3013346247 cites W2000157901 @default.
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- W3013346247 cites W2021432629 @default.
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- W3013346247 cites W2064696266 @default.
- W3013346247 cites W2071143412 @default.
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- W3013346247 cites W2083425643 @default.
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- W3013346247 cites W2097454127 @default.
- W3013346247 cites W2098272219 @default.
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- W3013346247 cites W2102526923 @default.
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- W3013346247 cites W2166261688 @default.
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- W3013346247 doi "https://doi.org/10.1016/j.scr.2020.101770" @default.
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