FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013347515> ?p ?o ?g. }

• W3013347515 endingPage "102017" @default.
• W3013347515 startingPage "102017" @default.
• W3013347515 abstract "When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical practice more than 15 years ago, it was one of the first targeted therapies and the first approved angiogenesis inhibitor. Marking the beginning for a new line of anti-cancer treatments, bevacizumab remains the most extensively characterized anti-angiogenetic treatment. Initially approved for treatment of metastatic colorectal cancer in combination with chemotherapy, its indications now include metastatic breast cancer, non-small-cell lung cancer, glioblastoma, renal cell carcinoma, ovarian cancer and cervical cancer. This review provides an overview of the clinical experience and lessons learned since bevacizumab’s initial approval, and highlights how this knowledge has led to the investigation of novel combination therapies.In the past 15 years, our understanding of VEGF’s role in the tumor microenvironment has evolved. We now know that VEGF not only plays a major role in controlling blood vessel formation, but also modulates tumor-induced immunosuppression. These immunomodulatory properties of bevacizumab have opened up new perspectives for combination therapy approaches, which are being investigated in clinical trials. Specifically, the combination of bevacizumab with cancer immunotherapy has recently been approved in non-small-cell lung cancer and clinical benefit was also demonstrated for treatment of hepatocellular carcinoma. However, despite intense investigation, reliable and validated biomarkers that would enable a more personalized use of bevacizumab remain elusive.Overall, bevacizumab is expected to remain a key agent in cancer therapy, both due to its established efficacy in approved indications and its promise as a partner in novel targeted combination treatments." @default.
• W3013347515 created "2020-04-03" @default.
• W3013347515 creator A5009234043 @default.
• W3013347515 creator A5012884004 @default.
• W3013347515 creator A5034105859 @default.
• W3013347515 creator A5040435806 @default.
• W3013347515 creator A5042329751 @default.
• W3013347515 creator A5046311492 @default.
• W3013347515 creator A5078389632 @default.
• W3013347515 date "2020-06-01" @default.
• W3013347515 modified "2023-10-14" @default.
• W3013347515 title "Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook" @default.
• W3013347515 cites W1539571840 @default.
• W3013347515 cites W1569162089 @default.
• W3013347515 cites W1793338775 @default.
• W3013347515 cites W1977601636 @default.
• W3013347515 cites W1987273470 @default.
• W3013347515 cites W1992487388 @default.
• W3013347515 cites W1995769259 @default.
• W3013347515 cites W2000292756 @default.
• W3013347515 cites W2010300658 @default.
• W3013347515 cites W2012852444 @default.
• W3013347515 cites W2017568769 @default.
• W3013347515 cites W2022540958 @default.
• W3013347515 cites W2032995169 @default.
• W3013347515 cites W2035182290 @default.
• W3013347515 cites W2037139573 @default.
• W3013347515 cites W2039589738 @default.
• W3013347515 cites W2050446445 @default.
• W3013347515 cites W2052375870 @default.
• W3013347515 cites W2095545927 @default.
• W3013347515 cites W2096396175 @default.
• W3013347515 cites W2100106896 @default.
• W3013347515 cites W2100669312 @default.
• W3013347515 cites W2100756525 @default.
• W3013347515 cites W2102306754 @default.
• W3013347515 cites W2103563357 @default.
• W3013347515 cites W2106951948 @default.
• W3013347515 cites W2109154357 @default.
• W3013347515 cites W2109491042 @default.
• W3013347515 cites W2111391096 @default.
• W3013347515 cites W2112759697 @default.
• W3013347515 cites W2113122060 @default.
• W3013347515 cites W2114783818 @default.
• W3013347515 cites W2115005218 @default.
• W3013347515 cites W2115330744 @default.
• W3013347515 cites W2117692326 @default.
• W3013347515 cites W2122730895 @default.
• W3013347515 cites W2122798232 @default.
• W3013347515 cites W2124736921 @default.
• W3013347515 cites W2125447919 @default.
• W3013347515 cites W2126275851 @default.
• W3013347515 cites W2128002599 @default.
• W3013347515 cites W2132697290 @default.
• W3013347515 cites W2135947389 @default.
• W3013347515 cites W2136601558 @default.
• W3013347515 cites W2140103603 @default.
• W3013347515 cites W2143743735 @default.
• W3013347515 cites W2144487043 @default.
• W3013347515 cites W2144660856 @default.
• W3013347515 cites W2145835533 @default.
• W3013347515 cites W2146412564 @default.
• W3013347515 cites W2148367564 @default.
• W3013347515 cites W2153982924 @default.
• W3013347515 cites W2155012968 @default.
• W3013347515 cites W2156330848 @default.
• W3013347515 cites W2157769714 @default.
• W3013347515 cites W2160373161 @default.
• W3013347515 cites W2160476851 @default.
• W3013347515 cites W2162645859 @default.
• W3013347515 cites W2167224460 @default.
• W3013347515 cites W2167422856 @default.
• W3013347515 cites W2170928115 @default.
• W3013347515 cites W2171658624 @default.
• W3013347515 cites W2195401033 @default.
• W3013347515 cites W2255518001 @default.
• W3013347515 cites W2279492741 @default.
• W3013347515 cites W2293809486 @default.
• W3013347515 cites W2335877573 @default.
• W3013347515 cites W2470575266 @default.
• W3013347515 cites W2473347405 @default.
• W3013347515 cites W2510561646 @default.
• W3013347515 cites W2538173625 @default.
• W3013347515 cites W2547100318 @default.
• W3013347515 cites W2589417649 @default.
• W3013347515 cites W2596332908 @default.
• W3013347515 cites W2597795073 @default.
• W3013347515 cites W2605456582 @default.
• W3013347515 cites W2612201027 @default.
• W3013347515 cites W2620065392 @default.
• W3013347515 cites W2626614537 @default.
• W3013347515 cites W2728245744 @default.
• W3013347515 cites W2742133220 @default.
• W3013347515 cites W2760893789 @default.
• W3013347515 cites W2763989048 @default.
• W3013347515 cites W2768388636 @default.
• W3013347515 cites W2768916192 @default.
• W3013347515 cites W2770920742 @default.

• next