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- W3013348624 endingPage "112262" @default.
- W3013348624 startingPage "112262" @default.
- W3013348624 abstract "The enzymes involved in bacterial cell wall synthesis are established antibiotic targets, and continue to be a central focus for antibiotic development. Bacterial penicillin-binding proteins (and, in some bacteria, l,d-transpeptidases) form essential peptide cross-links in the cell wall. Although the β-lactam class of antibiotics target these enzymes, bacterial resistance threatens their clinical use, and there is an urgent unmet need for new antibiotics. However, the search for new antibiotics targeting the bacterial cell wall is hindered by a number of obstacles associated with screening the enzymes involved in peptidoglycan synthesis. This review describes recent approaches for measuring the activity and inhibition of penicillin-binding proteins and l,d-transpeptidases, highlighting strategies that are poised to serve as valuable tools for high-throughput screening of transpeptidase inhibitors, supporting the development of new antibiotics." @default.
- W3013348624 created "2020-04-03" @default.
- W3013348624 creator A5045067042 @default.
- W3013348624 creator A5075747023 @default.
- W3013348624 date "2020-05-01" @default.
- W3013348624 modified "2023-10-14" @default.
- W3013348624 title "Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases" @default.
- W3013348624 cites W1478816797 @default.
- W3013348624 cites W1548036406 @default.
- W3013348624 cites W1550256141 @default.
- W3013348624 cites W1966070420 @default.
- W3013348624 cites W1967444320 @default.
- W3013348624 cites W1970523802 @default.
- W3013348624 cites W1978837389 @default.
- W3013348624 cites W1979304584 @default.
- W3013348624 cites W1980145079 @default.
- W3013348624 cites W1983769859 @default.
- W3013348624 cites W1985744248 @default.
- W3013348624 cites W1993341437 @default.
- W3013348624 cites W1996353262 @default.
- W3013348624 cites W1998385252 @default.
- W3013348624 cites W2001649292 @default.
- W3013348624 cites W2002668704 @default.
- W3013348624 cites W2003104921 @default.
- W3013348624 cites W2004235085 @default.
- W3013348624 cites W2006811585 @default.
- W3013348624 cites W2009001568 @default.
- W3013348624 cites W2009726576 @default.
- W3013348624 cites W2012047306 @default.
- W3013348624 cites W2014875604 @default.
- W3013348624 cites W2016891160 @default.
- W3013348624 cites W2018920177 @default.
- W3013348624 cites W2026542751 @default.
- W3013348624 cites W2027403968 @default.
- W3013348624 cites W2029207581 @default.
- W3013348624 cites W2029237250 @default.
- W3013348624 cites W2037087180 @default.
- W3013348624 cites W2042280213 @default.
- W3013348624 cites W2043283666 @default.
- W3013348624 cites W2044251513 @default.
- W3013348624 cites W2047025719 @default.
- W3013348624 cites W2049526353 @default.
- W3013348624 cites W2051240141 @default.
- W3013348624 cites W2052779789 @default.
- W3013348624 cites W2052865535 @default.
- W3013348624 cites W2053782254 @default.
- W3013348624 cites W2058958190 @default.
- W3013348624 cites W2063119446 @default.
- W3013348624 cites W2066527945 @default.
- W3013348624 cites W2067572953 @default.
- W3013348624 cites W2067950087 @default.
- W3013348624 cites W2069420516 @default.
- W3013348624 cites W2070190311 @default.
- W3013348624 cites W2079494225 @default.
- W3013348624 cites W2080878746 @default.
- W3013348624 cites W2081183202 @default.
- W3013348624 cites W2091992735 @default.
- W3013348624 cites W2102169587 @default.
- W3013348624 cites W2102906662 @default.
- W3013348624 cites W2105475356 @default.
- W3013348624 cites W2105999876 @default.
- W3013348624 cites W2111596834 @default.
- W3013348624 cites W2113845988 @default.
- W3013348624 cites W2114533737 @default.
- W3013348624 cites W2116738723 @default.
- W3013348624 cites W2123677996 @default.
- W3013348624 cites W2124486978 @default.
- W3013348624 cites W2134943478 @default.
- W3013348624 cites W2137364135 @default.
- W3013348624 cites W2141505411 @default.
- W3013348624 cites W2147532798 @default.
- W3013348624 cites W2152127318 @default.
- W3013348624 cites W2155398486 @default.
- W3013348624 cites W2158112023 @default.
- W3013348624 cites W2167800069 @default.
- W3013348624 cites W2170691032 @default.
- W3013348624 cites W2234058473 @default.
- W3013348624 cites W2300107644 @default.
- W3013348624 cites W2326951226 @default.
- W3013348624 cites W2329119724 @default.
- W3013348624 cites W2338739751 @default.
- W3013348624 cites W2344454939 @default.
- W3013348624 cites W2419712772 @default.
- W3013348624 cites W2515354748 @default.
- W3013348624 cites W2524034808 @default.
- W3013348624 cites W2532112416 @default.
- W3013348624 cites W2548232666 @default.
- W3013348624 cites W2558743206 @default.
- W3013348624 cites W2575699766 @default.
- W3013348624 cites W2606683200 @default.
- W3013348624 cites W2618803170 @default.
- W3013348624 cites W2784208342 @default.
- W3013348624 cites W2788772064 @default.
- W3013348624 cites W2795719567 @default.
- W3013348624 cites W2906206077 @default.
- W3013348624 cites W2912238261 @default.
- W3013348624 cites W2915828735 @default.
- W3013348624 cites W2955506675 @default.