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- W3013354562 abstract "A scientific review of current data on the effect of the genetic polymorphism of the most studied and proven candidate genome pharmacological targets involved in the lipid-lowering and clinical effect of statins is presented. Such candidate genes as APOE, СЕТР, HMGCR, LDL receptor, LPA, and KIF6 are examined and the results of studies and meta-analyzes confirming their effect on statin efficacy, mainly LDL and HDL levels are shown. Polymorphism of these genes promotes variability of hypolipidemic effect in real clinical practice and has interethnic features. Genotyping by predictive markers of pharmacodynamic effectiveness of statins can represent the basis of personalized medicine." @default.
- W3013354562 created "2020-04-03" @default.
- W3013354562 creator A5010477002 @default.
- W3013354562 date "2020-03-23" @default.
- W3013354562 modified "2023-09-25" @default.
- W3013354562 title "Фармакогенетика фармакодинамических мишеней действия статинов" @default.
- W3013354562 doi "https://doi.org/10.24411/2588-0527-2019-10035" @default.
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