FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013364263> ?p ?o ?g. }

• W3013364263 endingPage "778" @default.
• W3013364263 startingPage "770" @default.
• W3013364263 abstract "Abstract Background Superwarfarins, second-generation long-acting anticoagulant rodenticides, are 4-hydroxycoumarin analogues of warfarin that contain a large hydrophobic side chain. These compounds contain two chiral centers and are synthesized for commercial use as two pairs of diastereomer. Objective To support studies of superwarfarin pharmacokinetics and other efforts to improve clinical care for poisoning victims, a quantitative assay was developed for the measurement of diastereomer of bromadiolone, difenacoum, flocoumafen, brodifacoum, and difethialone in human plasma. Method Based on ultrahigh-pressure liquid chromatography-tandem mass-spectrometry (UHPLC-MS/MS), this method was validated according to U.S. Food and Drug Administration (FDA) guidelines. Sample preparation involved simple protein precipitation followed by reversed phase UHPLC, which resolved all five pairs of cis/trans diastereomer in less than 10 min. Superwarfarins were measured using negative ion electrospray followed by selected-reaction monitoring on a triple quadrupole mass spectrometer. Results Calibration curves covered 3–4 orders of magnitude with linear regression coefficients of &gt;0.999. The lower limits of quantitation were from 0.013 to 2.41 ng/mL, and intra-day and inter-day accuracy and precision coefficients of variation were &lt;12%. Conclusions A 10-min UHPLC-MS/MS assay was developed and validated for the separation and quantitative analysis of the pairs of diastereomer of five superwarfarins in human plasma. Highlights This method was used to identify and measure superwarfarins and their cis/trans diastereomers in plasma obtained from patients treated for coagulopathy following consumption of contaminated synthetic cannabinoid products." @default.
• W3013364263 created "2020-04-03" @default.
• W3013364263 creator A5021393795 @default.
• W3013364263 creator A5026872517 @default.
• W3013364263 creator A5036922002 @default.
• W3013364263 creator A5075513594 @default.
• W3013364263 date "2020-03-26" @default.
• W3013364263 modified "2023-10-18" @default.
• W3013364263 title "Separation and Quantification of Superwarfarin Rodenticide Diastereomers—Bromadiolone, Difenacoum, Flocoumafen, Brodifacoum, and Difethialone—in Human Plasma" @default.
• W3013364263 cites W1193367360 @default.
• W3013364263 cites W1425420639 @default.
• W3013364263 cites W1490470028 @default.
• W3013364263 cites W1586228188 @default.
• W3013364263 cites W180248143 @default.
• W3013364263 cites W1890620814 @default.
• W3013364263 cites W1970106581 @default.
• W3013364263 cites W1981202092 @default.
• W3013364263 cites W1991900237 @default.
• W3013364263 cites W1991917702 @default.
• W3013364263 cites W1992111447 @default.
• W3013364263 cites W1994333228 @default.
• W3013364263 cites W1995651891 @default.
• W3013364263 cites W1998050951 @default.
• W3013364263 cites W2000434595 @default.
• W3013364263 cites W2001883351 @default.
• W3013364263 cites W2012264988 @default.
• W3013364263 cites W2013334216 @default.
• W3013364263 cites W2014243870 @default.
• W3013364263 cites W2018035515 @default.
• W3013364263 cites W2022395566 @default.
• W3013364263 cites W2027016741 @default.
• W3013364263 cites W2035732532 @default.
• W3013364263 cites W2035929830 @default.
• W3013364263 cites W2036946450 @default.
• W3013364263 cites W2036984245 @default.
• W3013364263 cites W2040690190 @default.
• W3013364263 cites W2043660630 @default.
• W3013364263 cites W2046488799 @default.
• W3013364263 cites W2046835769 @default.
• W3013364263 cites W2049572524 @default.
• W3013364263 cites W2051857840 @default.
• W3013364263 cites W2060834347 @default.
• W3013364263 cites W2074679680 @default.
• W3013364263 cites W2079857213 @default.
• W3013364263 cites W2082535488 @default.
• W3013364263 cites W2094200207 @default.
• W3013364263 cites W2105651866 @default.
• W3013364263 cites W2108299219 @default.
• W3013364263 cites W2116228330 @default.
• W3013364263 cites W2121846489 @default.
• W3013364263 cites W2136043210 @default.
• W3013364263 cites W2144952325 @default.
• W3013364263 cites W2149820990 @default.
• W3013364263 cites W2152008649 @default.
• W3013364263 cites W2157626288 @default.
• W3013364263 cites W2160691359 @default.
• W3013364263 cites W2164143578 @default.
• W3013364263 cites W2171617939 @default.
• W3013364263 cites W2195444312 @default.
• W3013364263 cites W2245852274 @default.
• W3013364263 cites W2288899634 @default.
• W3013364263 cites W2413786274 @default.
• W3013364263 cites W2413953473 @default.
• W3013364263 cites W2501805935 @default.
• W3013364263 cites W2520651320 @default.
• W3013364263 cites W2558039848 @default.
• W3013364263 cites W2563773592 @default.
• W3013364263 cites W2573394178 @default.
• W3013364263 cites W2593957400 @default.
• W3013364263 cites W2760876314 @default.
• W3013364263 cites W2769266388 @default.
• W3013364263 cites W2770285406 @default.
• W3013364263 cites W2891089375 @default.
• W3013364263 cites W2894118435 @default.
• W3013364263 cites W2906806357 @default.
• W3013364263 cites W2911663770 @default.
• W3013364263 cites W82338835 @default.
• W3013364263 doi "https://doi.org/10.1093/jaoacint/qsaa007" @default.
• W3013364263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7372953" @default.
• W3013364263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33241367" @default.
• W3013364263 hasPublicationYear "2020" @default.
• W3013364263 type Work @default.
• W3013364263 sameAs 3013364263 @default.
• W3013364263 citedByCount "4" @default.
• W3013364263 countsByYear W30133642632021 @default.
• W3013364263 countsByYear W30133642632022 @default.
• W3013364263 crossrefType "journal-article" @default.
• W3013364263 hasAuthorship W3013364263A5021393795 @default.
• W3013364263 hasAuthorship W3013364263A5026872517 @default.
• W3013364263 hasAuthorship W3013364263A5036922002 @default.
• W3013364263 hasAuthorship W3013364263A5075513594 @default.
• W3013364263 hasBestOaLocation W30133642631 @default.
• W3013364263 hasConcept C138716334 @default.
• W3013364263 hasConcept C162356407 @default.
• W3013364263 hasConcept C172493649 @default.
• W3013364263 hasConcept C178790620 @default.
• W3013364263 hasConcept C185592680 @default.
• W3013364263 hasConcept C2775973874 @default.

• next