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- W301351094 abstract "This chapter describes the diagnosis and medical management of gastroenteropancreatic tumors. Gastroenteropancreatic tumors are usually slow growing; symptoms are often caused by secreted peptides rather than by tumor bulk alone, until a very late stage in the disease. Tumors are usually classified according to the products they secrete. Some tumors may be clinically silent if they produce biologically inactive peptides or if they secrete no peptides. Some tumors may produce a variety of peptides and therefore, the clinical presentation may be a mixed picture or one clinical syndrome may predominate. The islets of Langerhans are clusters of endocrine cells distributed throughout the endocrine pancreas and represent approximately 1% of the entire pancreatic mass. Four types of cells may be distinguished within the islet, each of which may develop into a tumor; the A cell produces glucagon that may become a glucagonoma; the β-cell produces insulin; the D cell produces somatostatin; and the PP cell produces pancreatic polypeptide. Insulinomas have been reported in patients of all ages from the newborn to the very elderly and peak incidence is between 40 and 60 years and the sex ratio is equal." @default.
- W301351094 created "2016-06-24" @default.
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- W301351094 date "1993-01-01" @default.
- W301351094 modified "2023-09-23" @default.
- W301351094 title "Diagnosis and Medical Management of Gastroenteropancreatic Tumours" @default.
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- W301351094 doi "https://doi.org/10.1016/b978-0-7506-1390-3.50045-3" @default.
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