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• W3013525872 abstract "We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which had retention times corresponding to PTX-1, -11, or -13. Hydrolysis products, such as PTX-2 seco acid, were not observed. Preliminary multi-stage LC-MS analyses indicated that the major hepatic PTX-2 metabolites resulted from the insertion of an oxygen atom at the positions C-19 to C-24, or at C-44. The rapid oxidative metabolism may explain the low oral toxicity of PTXs observed in vivo studies." @default.
• W3013525872 created "2020-04-03" @default.
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• W3013525872 date "2020-06-01" @default.
• W3013525872 modified "2023-10-17" @default.
• W3013525872 title "In vitro hepatic biotransformation of the algal toxin pectenotoxin-2" @default.
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• W3013525872 doi "https://doi.org/10.1016/j.toxcx.2020.100031" @default.
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