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• W3013534225 abstract "ObjectivesComprehensive local consolidative therapy led to improved overall survival in oligometastatic non–small cell lung cancer in a recent phase II trial, yet the role of pulmonary resection in ongoing oligometastatic trials is a matter of controversy. We sought to examine outcomes after pulmonary resection with radiotherapy used as a benchmark comparator.MethodsPatients treated at a single institution (2000-2017) with cT1-3N0-2M1 non–small cell lung cancer, 3 or less synchronous metastases, and performance status 0 to 1, and who received comprehensive local consolidative therapy were analyzed according to local consolidative therapy modality for the primary lesion. Progression was analyzed with death as a competing risk.ResultsOf 88 patients meeting inclusion criteria, 63 (71.6%) received radiotherapy for local consolidative therapy modality for the primary lesion and 25 (28.4%) underwent surgery (lobectomy 20/25 [80.0%], pneumonectomy 3/25 [12.0%], sublobar 2/25 [8.0%]). Time from diagnosis to local consolidative therapy modality for the primary lesion was similar. Surgical patients were younger and had lower intrathoracic disease burden. Ninety-day post-treatment mortality was low (surgery 0/25 [0.0%], radiotherapy 1/63 [1.6%]). Median postoperative survival time was 55.2 months (95% confidence interval, 20.1 to not reached), with 1- and 5-year overall survivals of 95.7% and 48.0%, respectively. After radiotherapy, median postoperative survival time was 23.4 months (confidence interval, 17.2-35.9); 1- and 5-year overall survivals were 74.3% and 24.2%, respectively. No differences were observed between modalities in site of first failure, cumulative incidence of locoregional failure (P = .635), or systemic progression (P = .747).ConclusionsPulmonary resection is feasible and associated with long-term survival in selected patients with synchronous oligometastatic non–small cell lung cancer. Surgery should remain a local consolidative therapeutic option for patients with operable oligometastatic non–small cell lung cancer enrolled in ongoing and future randomized clinical trials." @default.
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• W3013534225 date "2021-04-01" @default.
• W3013534225 modified "2023-10-18" @default.
• W3013534225 title "Pulmonary resection is associated with long-term survival and should remain a therapeutic option in oligometastatic lung cancer" @default.
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• W3013534225 doi "https://doi.org/10.1016/j.jtcvs.2020.02.134" @default.
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