Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013572561> ?p ?o ?g. }
- W3013572561 endingPage "1702.e6" @default.
- W3013572561 startingPage "1689" @default.
- W3013572561 abstract "ATP-binding cassette (ABC) transporters are the largest family of ATP-hydrolyzing transporters, which import or export substrates across membranes, and have members in every sequenced genome. Structural studies and biochemistry highlight the contrast between the global structural similarity of homologous transporters and the enormous diversity of their substrates. How do ABC transporters evolve to carry such diverse molecules and what variations in their amino acid sequence alter their substrate selectivity? We mutagenized the transmembrane domains of a conserved fungal ABC transporter that exports a mating pheromone and selected for mutants that export a non-cognate pheromone. Mutations that alter export selectivity cover a region that is larger than expected for a localized substrate-binding site. Individual selected clones have multiple mutations, which have broadly additive contributions to specific transport activity. Our results suggest that multiple positions influence substrate selectivity, leading to alternative evolutionary paths toward selectivity for particular substrates and explaining the number and diversity of ABC transporters." @default.
- W3013572561 created "2020-04-03" @default.
- W3013572561 creator A5020634412 @default.
- W3013572561 creator A5078386611 @default.
- W3013572561 creator A5079526241 @default.
- W3013572561 date "2020-05-01" @default.
- W3013572561 modified "2023-10-01" @default.
- W3013572561 title "Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibility of ATP-Binding Cassette Transporters" @default.
- W3013572561 cites W131157789 @default.
- W3013572561 cites W1489003654 @default.
- W3013572561 cites W1527774170 @default.
- W3013572561 cites W1721292595 @default.
- W3013572561 cites W1853445387 @default.
- W3013572561 cites W1912752546 @default.
- W3013572561 cites W1937597224 @default.
- W3013572561 cites W1992830366 @default.
- W3013572561 cites W1996112765 @default.
- W3013572561 cites W2000250937 @default.
- W3013572561 cites W2001216837 @default.
- W3013572561 cites W2004029458 @default.
- W3013572561 cites W2010683268 @default.
- W3013572561 cites W2012383157 @default.
- W3013572561 cites W2012987924 @default.
- W3013572561 cites W2016666153 @default.
- W3013572561 cites W2022690723 @default.
- W3013572561 cites W2031487956 @default.
- W3013572561 cites W2031611770 @default.
- W3013572561 cites W2037212291 @default.
- W3013572561 cites W2039599894 @default.
- W3013572561 cites W2047138447 @default.
- W3013572561 cites W2056085579 @default.
- W3013572561 cites W2059464705 @default.
- W3013572561 cites W2060588922 @default.
- W3013572561 cites W2069663555 @default.
- W3013572561 cites W2076954063 @default.
- W3013572561 cites W2077301629 @default.
- W3013572561 cites W2078489870 @default.
- W3013572561 cites W2079701876 @default.
- W3013572561 cites W2085195403 @default.
- W3013572561 cites W2088693217 @default.
- W3013572561 cites W2106087641 @default.
- W3013572561 cites W2106941934 @default.
- W3013572561 cites W2111997766 @default.
- W3013572561 cites W2116829404 @default.
- W3013572561 cites W2120875352 @default.
- W3013572561 cites W2122683100 @default.
- W3013572561 cites W2128262754 @default.
- W3013572561 cites W2135636849 @default.
- W3013572561 cites W2137441463 @default.
- W3013572561 cites W2140744545 @default.
- W3013572561 cites W2144175569 @default.
- W3013572561 cites W2154248614 @default.
- W3013572561 cites W2154926703 @default.
- W3013572561 cites W2159614853 @default.
- W3013572561 cites W2164048622 @default.
- W3013572561 cites W2167279371 @default.
- W3013572561 cites W2169333620 @default.
- W3013572561 cites W2178203671 @default.
- W3013572561 cites W2234497665 @default.
- W3013572561 cites W2276307659 @default.
- W3013572561 cites W2376573086 @default.
- W3013572561 cites W2471654536 @default.
- W3013572561 cites W2474522617 @default.
- W3013572561 cites W2580035316 @default.
- W3013572561 cites W2580288737 @default.
- W3013572561 cites W2580516112 @default.
- W3013572561 cites W2589923912 @default.
- W3013572561 cites W274783243 @default.
- W3013572561 cites W2753791808 @default.
- W3013572561 cites W2769024665 @default.
- W3013572561 cites W2777467795 @default.
- W3013572561 cites W2789199387 @default.
- W3013572561 cites W2790509526 @default.
- W3013572561 cites W2796552195 @default.
- W3013572561 cites W2799424199 @default.
- W3013572561 cites W2801498120 @default.
- W3013572561 cites W2804822363 @default.
- W3013572561 cites W2899763402 @default.
- W3013572561 cites W2906494960 @default.
- W3013572561 cites W2908521132 @default.
- W3013572561 cites W2908537516 @default.
- W3013572561 cites W2913173637 @default.
- W3013572561 cites W2952870781 @default.
- W3013572561 cites W2957093526 @default.
- W3013572561 cites W2970005728 @default.
- W3013572561 cites W3102583847 @default.
- W3013572561 cites W4236860969 @default.
- W3013572561 cites W4313333803 @default.
- W3013572561 doi "https://doi.org/10.1016/j.cub.2020.02.077" @default.
- W3013572561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7243462" @default.
- W3013572561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32220325" @default.
- W3013572561 hasPublicationYear "2020" @default.
- W3013572561 type Work @default.
- W3013572561 sameAs 3013572561 @default.
- W3013572561 citedByCount "13" @default.
- W3013572561 countsByYear W30135725612020 @default.
- W3013572561 countsByYear W30135725612021 @default.
- W3013572561 countsByYear W30135725612022 @default.