Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013617195> ?p ?o ?g. }
- W3013617195 endingPage "FDD37" @default.
- W3013617195 startingPage "FDD37" @default.
- W3013617195 abstract "Aim: R18D is a poly-arginine peptide that has demonstrated neuroprotection in preclinical models of excitotoxicity, stroke, hypoxic-ischemic encephalopathy and traumatic brain injury. Here, we examined the peptide’s uptake in serum. Materials & methods: Healthy, male Sprague–Dawley rats were intravenously administered either 1000 nmol/kg R18D (D-enantiomer of R18) or approximately 2.5 nmol/kg (36 ± 9 MBq) [ 18 F]R18D, for serum and organ tissue uptake, respectively. Serum samples underwent mass spectrometric analysis to detect unbound R18D peptide. Animals administered [ 18 F]R18D were subjected to positron emission tomography imaging. Results & conclusion: Free R18D was detected at 5 min post-infusion in serum samples. [ 18 F]R18D was rapidly distributed to the kidney (6–7%ID/g), and a small fraction localized to the brain (0.115–0.123%ID/g) over a 60-min acquisition period." @default.
- W3013617195 created "2020-04-03" @default.
- W3013617195 creator A5007846768 @default.
- W3013617195 creator A5010631496 @default.
- W3013617195 creator A5039389525 @default.
- W3013617195 creator A5041090849 @default.
- W3013617195 creator A5049716242 @default.
- W3013617195 creator A5068214104 @default.
- W3013617195 creator A5083984852 @default.
- W3013617195 creator A5084014102 @default.
- W3013617195 date "2020-04-01" @default.
- W3013617195 modified "2023-10-16" @default.
- W3013617195 title "Tissue distribution of intravenously administrated poly-arginine peptide R18D in healthy male Sprague–Dawley rats" @default.
- W3013617195 cites W1966404481 @default.
- W3013617195 cites W1969785724 @default.
- W3013617195 cites W1980795483 @default.
- W3013617195 cites W1984434100 @default.
- W3013617195 cites W1988487044 @default.
- W3013617195 cites W1996920444 @default.
- W3013617195 cites W2010870296 @default.
- W3013617195 cites W2038283518 @default.
- W3013617195 cites W2050167321 @default.
- W3013617195 cites W2103672776 @default.
- W3013617195 cites W2106161469 @default.
- W3013617195 cites W2132502850 @default.
- W3013617195 cites W2346596958 @default.
- W3013617195 cites W2519095390 @default.
- W3013617195 cites W2551280162 @default.
- W3013617195 cites W2563311768 @default.
- W3013617195 cites W2588262749 @default.
- W3013617195 cites W2614969868 @default.
- W3013617195 cites W2759659722 @default.
- W3013617195 cites W2769348921 @default.
- W3013617195 cites W2771787078 @default.
- W3013617195 cites W2793029827 @default.
- W3013617195 cites W2805227554 @default.
- W3013617195 cites W2906810009 @default.
- W3013617195 cites W581235682 @default.
- W3013617195 doi "https://doi.org/10.4155/fdd-2019-0039" @default.
- W3013617195 hasPublicationYear "2020" @default.
- W3013617195 type Work @default.
- W3013617195 sameAs 3013617195 @default.
- W3013617195 citedByCount "0" @default.
- W3013617195 crossrefType "journal-article" @default.
- W3013617195 hasAuthorship W3013617195A5007846768 @default.
- W3013617195 hasAuthorship W3013617195A5010631496 @default.
- W3013617195 hasAuthorship W3013617195A5039389525 @default.
- W3013617195 hasAuthorship W3013617195A5041090849 @default.
- W3013617195 hasAuthorship W3013617195A5049716242 @default.
- W3013617195 hasAuthorship W3013617195A5068214104 @default.
- W3013617195 hasAuthorship W3013617195A5083984852 @default.
- W3013617195 hasAuthorship W3013617195A5084014102 @default.
- W3013617195 hasBestOaLocation W30136171951 @default.
- W3013617195 hasConcept C110121322 @default.
- W3013617195 hasConcept C126322002 @default.
- W3013617195 hasConcept C127413603 @default.
- W3013617195 hasConcept C134018914 @default.
- W3013617195 hasConcept C134306372 @default.
- W3013617195 hasConcept C170493617 @default.
- W3013617195 hasConcept C185592680 @default.
- W3013617195 hasConcept C25498285 @default.
- W3013617195 hasConcept C2777468819 @default.
- W3013617195 hasConcept C2778621155 @default.
- W3013617195 hasConcept C2779281246 @default.
- W3013617195 hasConcept C2780645631 @default.
- W3013617195 hasConcept C2781012912 @default.
- W3013617195 hasConcept C33923547 @default.
- W3013617195 hasConcept C515207424 @default.
- W3013617195 hasConcept C55493867 @default.
- W3013617195 hasConcept C61174792 @default.
- W3013617195 hasConcept C71924100 @default.
- W3013617195 hasConcept C78519656 @default.
- W3013617195 hasConcept C98274493 @default.
- W3013617195 hasConceptScore W3013617195C110121322 @default.
- W3013617195 hasConceptScore W3013617195C126322002 @default.
- W3013617195 hasConceptScore W3013617195C127413603 @default.
- W3013617195 hasConceptScore W3013617195C134018914 @default.
- W3013617195 hasConceptScore W3013617195C134306372 @default.
- W3013617195 hasConceptScore W3013617195C170493617 @default.
- W3013617195 hasConceptScore W3013617195C185592680 @default.
- W3013617195 hasConceptScore W3013617195C25498285 @default.
- W3013617195 hasConceptScore W3013617195C2777468819 @default.
- W3013617195 hasConceptScore W3013617195C2778621155 @default.
- W3013617195 hasConceptScore W3013617195C2779281246 @default.
- W3013617195 hasConceptScore W3013617195C2780645631 @default.
- W3013617195 hasConceptScore W3013617195C2781012912 @default.
- W3013617195 hasConceptScore W3013617195C33923547 @default.
- W3013617195 hasConceptScore W3013617195C515207424 @default.
- W3013617195 hasConceptScore W3013617195C55493867 @default.
- W3013617195 hasConceptScore W3013617195C61174792 @default.
- W3013617195 hasConceptScore W3013617195C71924100 @default.
- W3013617195 hasConceptScore W3013617195C78519656 @default.
- W3013617195 hasConceptScore W3013617195C98274493 @default.
- W3013617195 hasIssue "2" @default.
- W3013617195 hasLocation W30136171951 @default.
- W3013617195 hasLocation W30136171952 @default.
- W3013617195 hasOpenAccess W3013617195 @default.
- W3013617195 hasPrimaryLocation W30136171951 @default.