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- W3013619085 abstract "The natural product veranamine was isolated from the marine sponge Verongula rigida. It contains a unique heterocyclic scaffold and demonstrates in vivo antidepressant activity and selective affinity for 5HT2B and sigma-1 receptors. The first total synthesis of veranamine is reported. Our scalable synthesis offers veranamine in six steps and 25% yield via an unprecedented vinylogous Pictet-Gams pyridine formation strategy. Veranamine is a promising new lead compound for antidepressant drug development." @default.
- W3013619085 created "2020-04-03" @default.
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- W3013619085 date "2020-03-31" @default.
- W3013619085 modified "2023-10-18" @default.
- W3013619085 title "Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge <i>Verongula rigida</i>" @default.
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- W3013619085 doi "https://doi.org/10.1021/acs.jnatprod.9b01107" @default.
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