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- W3013656928 abstract "SUMMARY The hypothalamo-neurohypophysial system (HNS), comprising hypothalamic magnocellular neuroendocrine cells (MNCs) and the neurohypophysis, plays a pivotal role in regulating reproduction and fluid homeostasis by releasing oxytocin and vasopressin into the bloodstream. However, it remains incompletely understood on its structure and whether it contributes to the central actions of oxytocin and vasopressin. Using viral tracing and whole brain imaging, we reconstructed the three-dimensional architecture of the HNS and uncovered that subsets of MNCs collaterally project to multiple extrahypothalamic regions. Moreover, selective activation of magnocellular oxytocin neurons promoted peripheral oxytocin release and facilitated central oxytocin-mediated social interactions. Further, MNCs-released oxytocin in the caudate putamen enhanced locomotion to orchestrate social investigation. Our work reveals the previously unrecognized complexity of the HNS and provides structural and functional evidence for MNCs in coordinating both peripheral and central oxytocin-mediated actions, which will shed light on the mechanistic understanding of oxytocin-related psychiatric diseases." @default.
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- W3013656928 date "2020-03-26" @default.
- W3013656928 modified "2023-10-16" @default.
- W3013656928 title "Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain" @default.
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- W3013656928 doi "https://doi.org/10.1101/2020.03.26.007070" @default.
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