Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013661856> ?p ?o ?g. }
- W3013661856 endingPage "106426" @default.
- W3013661856 startingPage "106426" @default.
- W3013661856 abstract "Inflammatory bowel disease could result in diarrhea and abdominal pain, as well as potential complications such as tissue fibrosis. The therapeutic effect of andrographolide sulfonate on acute murine experimental colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) has been confirmed. In the study here, chronic colitis triggered by repeated intrarectal administration of TNBS was established and the effect of andrographolide sulfonate was examined. Repeated TNBS administration induced substantial mice death, which was significantly decreased by andrographolide sulfonate treatment. The elevation of inflammatory cytokines including IL-6, IL-17A, TNF-α as well as IFN-γ in colonic tissues levels were decreased after administration of andrographolide sulfonate. Next, CD4+ T cell and macrophage infiltration was found to descend. The subset of pathogenic CD4+ T cell subset including CD4+IFN-γ+ (Th1) and CD4+IL-17A+ (Th17) were also suppressed by andrographolide sulfonate. Further, the restrain of p38 and p65 activation were also observed after andrographolide sulfonate administration. Finally, TNBS-induced colonic epithelial damage as well as fibrosis were significantly mitigated by andrographolide sulfonate. Based on the results got here, we can make a conclusion that andrographolide sulfonate could decrease inflammation and epithelial damage as well as fibrosis thus ameliorating chronic colitis in mice. Our study suggest the possible use of andrographolide sulfonate for chronic colitis treatment in clinical." @default.
- W3013661856 created "2020-04-03" @default.
- W3013661856 creator A5001969147 @default.
- W3013661856 creator A5003755362 @default.
- W3013661856 creator A5006890585 @default.
- W3013661856 creator A5013345074 @default.
- W3013661856 creator A5031086488 @default.
- W3013661856 creator A5038755507 @default.
- W3013661856 creator A5051351970 @default.
- W3013661856 creator A5056364957 @default.
- W3013661856 creator A5057421048 @default.
- W3013661856 creator A5071337286 @default.
- W3013661856 date "2020-06-01" @default.
- W3013661856 modified "2023-10-16" @default.
- W3013661856 title "Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis" @default.
- W3013661856 cites W1608424471 @default.
- W3013661856 cites W1952598732 @default.
- W3013661856 cites W1964847767 @default.
- W3013661856 cites W1973397356 @default.
- W3013661856 cites W1985967927 @default.
- W3013661856 cites W1991081070 @default.
- W3013661856 cites W1995143704 @default.
- W3013661856 cites W2002394315 @default.
- W3013661856 cites W2005224639 @default.
- W3013661856 cites W2011356699 @default.
- W3013661856 cites W2017443683 @default.
- W3013661856 cites W2021780874 @default.
- W3013661856 cites W2033436774 @default.
- W3013661856 cites W2034817600 @default.
- W3013661856 cites W2038122919 @default.
- W3013661856 cites W2040391599 @default.
- W3013661856 cites W2057024358 @default.
- W3013661856 cites W2064645845 @default.
- W3013661856 cites W2070715537 @default.
- W3013661856 cites W2072863782 @default.
- W3013661856 cites W2080977583 @default.
- W3013661856 cites W2166710590 @default.
- W3013661856 cites W2168337532 @default.
- W3013661856 cites W2182578492 @default.
- W3013661856 cites W2193392580 @default.
- W3013661856 cites W2286735596 @default.
- W3013661856 cites W2311739205 @default.
- W3013661856 cites W2317391245 @default.
- W3013661856 cites W2339102023 @default.
- W3013661856 cites W2529401211 @default.
- W3013661856 cites W2583464358 @default.
- W3013661856 cites W2588714305 @default.
- W3013661856 cites W2617856800 @default.
- W3013661856 cites W2620756707 @default.
- W3013661856 cites W2757756934 @default.
- W3013661856 cites W2766046358 @default.
- W3013661856 cites W2887086109 @default.
- W3013661856 cites W2903540483 @default.
- W3013661856 cites W2907914930 @default.
- W3013661856 cites W2949971221 @default.
- W3013661856 cites W2953285292 @default.
- W3013661856 cites W2963354234 @default.
- W3013661856 cites W2975213891 @default.
- W3013661856 cites W2975993852 @default.
- W3013661856 cites W2977581039 @default.
- W3013661856 cites W2991550463 @default.
- W3013661856 cites W2996552716 @default.
- W3013661856 cites W3000133404 @default.
- W3013661856 cites W4250731522 @default.
- W3013661856 doi "https://doi.org/10.1016/j.intimp.2020.106426" @default.
- W3013661856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32220806" @default.
- W3013661856 hasPublicationYear "2020" @default.
- W3013661856 type Work @default.
- W3013661856 sameAs 3013661856 @default.
- W3013661856 citedByCount "19" @default.
- W3013661856 countsByYear W30136618562020 @default.
- W3013661856 countsByYear W30136618562021 @default.
- W3013661856 countsByYear W30136618562022 @default.
- W3013661856 countsByYear W30136618562023 @default.
- W3013661856 crossrefType "journal-article" @default.
- W3013661856 hasAuthorship W3013661856A5001969147 @default.
- W3013661856 hasAuthorship W3013661856A5003755362 @default.
- W3013661856 hasAuthorship W3013661856A5006890585 @default.
- W3013661856 hasAuthorship W3013661856A5013345074 @default.
- W3013661856 hasAuthorship W3013661856A5031086488 @default.
- W3013661856 hasAuthorship W3013661856A5038755507 @default.
- W3013661856 hasAuthorship W3013661856A5051351970 @default.
- W3013661856 hasAuthorship W3013661856A5056364957 @default.
- W3013661856 hasAuthorship W3013661856A5057421048 @default.
- W3013661856 hasAuthorship W3013661856A5071337286 @default.
- W3013661856 hasConcept C126322002 @default.
- W3013661856 hasConcept C178790620 @default.
- W3013661856 hasConcept C185592680 @default.
- W3013661856 hasConcept C203014093 @default.
- W3013661856 hasConcept C2775862500 @default.
- W3013661856 hasConcept C2776914184 @default.
- W3013661856 hasConcept C2778894819 @default.
- W3013661856 hasConcept C2780559512 @default.
- W3013661856 hasConcept C2781357234 @default.
- W3013661856 hasConcept C537181965 @default.
- W3013661856 hasConcept C71924100 @default.
- W3013661856 hasConcept C98274493 @default.
- W3013661856 hasConceptScore W3013661856C126322002 @default.