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- W3013664579 abstract "旨在检测嗜酸乳杆菌S-层蛋白以及S-层蛋白与抗生素联用对大肠杆菌（Escherichia coli）和金黄色葡萄球菌（Staphylococcus aureus）的抑制作用。采用液体发酵培养法获得嗜酸乳杆菌菌体，LiCl法提取S-层蛋白粗提物，凝胶过滤层析法纯化S-层蛋白，分别用E.coli和S.aureus处理Caco-2细胞2 h后，考察S-层蛋白在不同浓度和不同作用时间条件下对E.coli和S.aureus的抑制作用，并考察S-层蛋白联合抗生素对E.coli和S.aureus的抑制作用，实验分组：（1）空白对照；（2）嗜酸乳杆菌组；（3）S-层蛋白组；（4）抗生素组；（5）嗜酸乳杆菌+抗生素组；（6）S-层蛋白+抗生素组。结果显示，液体发酵得到嗜酸乳杆菌菌体，提取并纯化得到S-层蛋白；S-层蛋白对E.coli和S.aureus有很好的抑制效果，具有浓度依赖性，高浓度下抑制率达到42.2%和31.7%，差异极显著（P < 0.01），且在E.coli和S.aureus作用的短时间内干预效果明显，0 h时的抑制率分别达到59.3%和48.4%；S-层蛋白联合抗生素的抑菌率分别达到81.7%和79.3%，差异极显著（P < 0.01），效果优于单独使用抗生素。嗜酸乳杆菌S-层蛋白具有较强的抑菌作用，可以与抗生素联用，有望开发称为一种新型的抗菌药物。" @default.
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- W3013664579 date "2020-03-26" @default.
- W3013664579 modified "2023-10-18" @default.
- W3013664579 title "嗜酸乳杆菌S-层蛋白联合抗生素对 Escherichia coli 和 Staphylococcus aureus 的抑制作用研究" @default.
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