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• W3013669503 startingPage "83" @default.
• W3013669503 abstract "Abstract Breast cancer (BC) is one of the most common malignancies globally in women, with high mortality rate as a result of tumour metastasis. MicroRNAs play vital roles in the occurrence and development of human cancer. This study aimed to investigate the biological roles of miR-1323 in BC. The expression levels of miR-1323 were detected by quantitative real-time PCR assay. The effect of miR-1323 on BC cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assay. Wound healing analysis and Matrigel Transwell assay were conducted to evaluate miR-1323-mediated BC cell migration and invasion. A luciferase reporter assay was used to test the target of miR-1323. We found that miR-1323 levels were downregulated in BC tissues and serums. Low-miR-1323 levels were associated with lymph node metastasis and advanced clinical stage. Tumour protein D52 (TPD52) was identified as a direct target of miR-1323. Low expression of miR-1323 contributed to the overexpression of TPD52 leading to enhanced BC progression. Our findings suggest that silencing of miR-1323 enhances BC development by regulating TPD52 expression, suggesting that miR-1323 and TPD52 may serve as potential therapeutic targets for BC treatment." @default.
• W3013669503 created "2020-04-03" @default.
• W3013669503 creator A5037907612 @default.
• W3013669503 creator A5044680328 @default.
• W3013669503 date "2020-03-25" @default.
• W3013669503 modified "2023-09-23" @default.
• W3013669503 title "MicroRNA-1323 downregulation promotes migration and invasion of breast cancer cells by targeting tumour protein D52" @default.
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• W3013669503 doi "https://doi.org/10.1093/jb/mvaa035" @default.
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