Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013687974> ?p ?o ?g. }
- W3013687974 abstract "Hypertension is a clinical cardiovascular syndrome characterized by elevated systemic arterial pressure with or without multiple cardiovascular risk factors. Radix Pueraria (RP) has the effects of anti-myocardial ischemia, anti-arrhythmia, vasodilatation, blood pressure reduction, anti-inflammation and attenuating insulin resistance. Although RP can be effective for the treatment of hypertension, its active compounds, drug targets, and exact molecular mechanism are still unclear. In this study, systems pharmacology was used to analyze the active compounds, drug target genes and key pathways of RP in the treatment of hypertension. Thirteen active compounds and related information on RP were obtained from the TCMSP database, and 140 overlapping genes related to hypertension and drugs were obtained from the GeneCards and OMIM databases. A PPI network and a traditional Chinese medicine (TCM) comprehensive network (Drug-Compounds-Genes-Disease network) were constructed, and 2246 GO terms and 157 pathways were obtained by GO enrichment analysis and KEGG pathway enrichment analysis. Some important active compounds and targets were evaluated by in vitro experiments. This study shows that RP probably acts by influencing the proliferation module, apoptosis module, inflammation module, and others when treating hypertension. This study provides novel insights for researchers to systematically explore the mechanism of action of TCM." @default.
- W3013687974 created "2020-04-03" @default.
- W3013687974 creator A5003501484 @default.
- W3013687974 creator A5018814025 @default.
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- W3013687974 creator A5067768314 @default.
- W3013687974 creator A5073357590 @default.
- W3013687974 creator A5084811923 @default.
- W3013687974 date "2020-03-24" @default.
- W3013687974 modified "2023-09-30" @default.
- W3013687974 title "Systems Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Radix Puerariae for Treatment of Hypertension" @default.
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