Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013708081> ?p ?o ?g. }
- W3013708081 abstract "Abstract Objective To examine the association of erythrocyte n-6 polyunsaturated fatty acid (PUFA) biomarkers with incident type 2 diabetes (T2D) and explore the potential role of gut microbiota in the association. Design We evaluated 2,731 non-T2D participants recruited between 2008-2013 in the Guangzhou Nutrition and Health Study, China. T2D cases were identified with clinical and biochemical information collected at follow-up visits. Using stool samples collected during the follow-up in the subset (n=1,591), 16S rRNA profiling was conducted. Using multivariable-adjusted Poisson or linear regression, we examined associations of erythrocyte n-6 PUFA biomarkers with incident T2D, and diversity and composition of gut microbiota. Results Over 6.2 years of follow-up, 276 T2D cases were identified (risk=0.10). Higher levels of erythrocyte γ-linolenic acid (GLA), but not linoleic or arachidonic acid, were associated with higher T2D incidence. Comparing the top to the bottom quartile groups of GLA levels, relative risk was 1.72 (95% confidence intervals: 1.21, 2.44) adjusted for potential confounders. Baseline GLA was inversely associated with gut microbial richness and diversity (α-diversity, both p <0.05) during follow-up, and significantly associated with microbiota β-diversity ( p =0.002). Seven genera ( Butyrivibrio, Blautia, Oscillospira, Odoribacter, S24-7 other, Rikenellaceae other , and Clostridiales other ) were enriched in quartile 1 of GLA, and in participants without T2D. Conclusion Relative concentrations of erythrocyte GLA were positively associated with incident T2D in a Chinese population and also with gut microbial profiles. These results highlight that gut microbiota may play an important role linking n-6 PUFA metabolism and T2D etiology." @default.
- W3013708081 created "2020-04-03" @default.
- W3013708081 creator A5003964350 @default.
- W3013708081 creator A5016333925 @default.
- W3013708081 creator A5021846370 @default.
- W3013708081 creator A5026338064 @default.
- W3013708081 creator A5041764652 @default.
- W3013708081 creator A5044543844 @default.
- W3013708081 creator A5061488870 @default.
- W3013708081 creator A5062572385 @default.
- W3013708081 creator A5068466167 @default.
- W3013708081 creator A5069247137 @default.
- W3013708081 creator A5070324150 @default.
- W3013708081 creator A5072606882 @default.
- W3013708081 creator A5078004741 @default.
- W3013708081 creator A5079359888 @default.
- W3013708081 creator A5083841540 @default.
- W3013708081 date "2020-03-30" @default.
- W3013708081 modified "2023-10-17" @default.
- W3013708081 title "Erythrocyte n-6 polyunsaturated fatty acids, gut microbiota and incident type 2 diabetes: a prospective cohort study" @default.
- W3013708081 cites W1592407962 @default.
- W3013708081 cites W1988925586 @default.
- W3013708081 cites W2035885128 @default.
- W3013708081 cites W2038217946 @default.
- W3013708081 cites W2042183374 @default.
- W3013708081 cites W2043413905 @default.
- W3013708081 cites W2056526409 @default.
- W3013708081 cites W2071841602 @default.
- W3013708081 cites W2072970694 @default.
- W3013708081 cites W2085702556 @default.
- W3013708081 cites W2089246633 @default.
- W3013708081 cites W2116369874 @default.
- W3013708081 cites W2129205142 @default.
- W3013708081 cites W2131536322 @default.
- W3013708081 cites W2133010654 @default.
- W3013708081 cites W2133856765 @default.
- W3013708081 cites W2137485611 @default.
- W3013708081 cites W2144662796 @default.
- W3013708081 cites W2155782413 @default.
- W3013708081 cites W2170410023 @default.
- W3013708081 cites W2217305406 @default.
- W3013708081 cites W2292502644 @default.
- W3013708081 cites W2299913967 @default.
- W3013708081 cites W2302624537 @default.
- W3013708081 cites W2461706302 @default.
- W3013708081 cites W2486972204 @default.
- W3013708081 cites W2546627493 @default.
- W3013708081 cites W2566680380 @default.
- W3013708081 cites W2662258145 @default.
- W3013708081 cites W2744283034 @default.
- W3013708081 cites W2761254197 @default.
- W3013708081 cites W2763226628 @default.
- W3013708081 cites W2789495752 @default.
- W3013708081 cites W2908757720 @default.
- W3013708081 cites W2915433988 @default.
- W3013708081 cites W2937090594 @default.
- W3013708081 cites W2962894734 @default.
- W3013708081 cites W2977990342 @default.
- W3013708081 cites W4210406501 @default.
- W3013708081 cites W4241151929 @default.
- W3013708081 cites W935038218 @default.
- W3013708081 doi "https://doi.org/10.1101/2020.03.29.20039693" @default.
- W3013708081 hasPublicationYear "2020" @default.
- W3013708081 type Work @default.
- W3013708081 sameAs 3013708081 @default.
- W3013708081 citedByCount "0" @default.
- W3013708081 crossrefType "posted-content" @default.
- W3013708081 hasAuthorship W3013708081A5003964350 @default.
- W3013708081 hasAuthorship W3013708081A5016333925 @default.
- W3013708081 hasAuthorship W3013708081A5021846370 @default.
- W3013708081 hasAuthorship W3013708081A5026338064 @default.
- W3013708081 hasAuthorship W3013708081A5041764652 @default.
- W3013708081 hasAuthorship W3013708081A5044543844 @default.
- W3013708081 hasAuthorship W3013708081A5061488870 @default.
- W3013708081 hasAuthorship W3013708081A5062572385 @default.
- W3013708081 hasAuthorship W3013708081A5068466167 @default.
- W3013708081 hasAuthorship W3013708081A5069247137 @default.
- W3013708081 hasAuthorship W3013708081A5070324150 @default.
- W3013708081 hasAuthorship W3013708081A5072606882 @default.
- W3013708081 hasAuthorship W3013708081A5078004741 @default.
- W3013708081 hasAuthorship W3013708081A5079359888 @default.
- W3013708081 hasAuthorship W3013708081A5083841540 @default.
- W3013708081 hasBestOaLocation W30137080811 @default.
- W3013708081 hasConcept C126322002 @default.
- W3013708081 hasConcept C134018914 @default.
- W3013708081 hasConcept C156957248 @default.
- W3013708081 hasConcept C19038510 @default.
- W3013708081 hasConcept C203014093 @default.
- W3013708081 hasConcept C2777180221 @default.
- W3013708081 hasConcept C2780809830 @default.
- W3013708081 hasConcept C2908647359 @default.
- W3013708081 hasConcept C539455810 @default.
- W3013708081 hasConcept C543025807 @default.
- W3013708081 hasConcept C55493867 @default.
- W3013708081 hasConcept C555293320 @default.
- W3013708081 hasConcept C71924100 @default.
- W3013708081 hasConcept C86803240 @default.
- W3013708081 hasConcept C99454951 @default.
- W3013708081 hasConceptScore W3013708081C126322002 @default.
- W3013708081 hasConceptScore W3013708081C134018914 @default.