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- W3013710921 abstract "Male infertility is becoming a rapidly growing problem around the world, mainly in the highly developed countries. Seminal proteome composition seems to be one of the crucial factors of the proper course of fertilization - clusterin (CLU) is among the most important ones. CLU, as one of the crucial seminal plasma glycoproteins, plays a very important role in sperm capacitation and immune tolerance in the female reproductive tract. CLU is also known as a sensitive marker of oxidative stress. It has six n-glycosylation sites and also exhibits chaperone activity. An analysis of changes in the profile and degree of CLU glycosylation may shed some new light on the molecular mechanisms of the fertilization process and may be used as an additional diagnostic marker of male fertility. This study constitutes a review of the recently available literature concerning human seminal CLU, including changes in its glycosylation, analyzed in the context of human reproduction." @default.
- W3013710921 created "2020-04-03" @default.
- W3013710921 creator A5040989895 @default.
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- W3013710921 date "2020-03-28" @default.
- W3013710921 modified "2023-09-25" @default.
- W3013710921 title "Could the glycosylation analysis of seminal plasma clusterin become a novel male infertility biomarker?" @default.
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- W3013710921 doi "https://doi.org/10.1002/mrd.23340" @default.
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