FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013737655> ?p ?o ?g. }

• W3013737655 endingPage "796" @default.
• W3013737655 startingPage "795" @default.
• W3013737655 abstract "To the Editor: Although focal balloon cell changes of the melanocytes are relatively frequent, pure balloon cell lesions, defined as lesions mostly (>50%) composed of balloon cells, are exceedingly rare. In the literature, they represent about 1.7% of skin nevi1 and 1% of skin melanomas.2 Nevertheless, ballooning has been reported in a wide spectrum of benign and malignant melanocytic lesions in the skin and in the mucosa. In the skin, ballooning of the melanocytes can occur in blue, Spitz, halo, combined, and dysplastic nevi, as well as in melanomas. Balloon cell melanomas can be both superficial spreading and nodular but are invariably invasive. In addition, the growth at the epidermal junction is very rare, and the neoplastic proliferation is mainly dermal based. We report the case of an otherwise healthy 55-year-old woman who presented with a 1-cm melanocytic lesion on her back. The lesion was completely excised. At histology, a broad proliferation of small nests and single atypical clear cells was present, limited to the epidermis. All the cells showed large ballooned cytoplasm and centrally located oval nuclei, providing a sebocyte-like appearance (Figs. 1 and 2). Pagetoid spread till the stratum corneum was prominent. No neoplastic cells were visible in the dermis. Immunohistochemical staining with HMB45 (Fig. 3) was positive, and a diagnosis of balloon cell in situ melanoma was rendered.FIGURE 1.: Small nests and single cells with diffuse ballooning of the cytoplasm, limited to the epidermis, and with prominent pagetoid spread.FIGURE 2.: At higher magnification, balloon melanocytes show a wide clear cytoplasm and a centrally located oval nucleus, providing a sebocyte-like appearance.FIGURE 3.: Immunohistochemical staining with HMB45 is strongly positive.In the surgical re-excision, no residual melanoma was present. A balloon melanocyte is a large cell with abundant vacuolized cytoplasm and a centrally located oval nucleus. Recently, balloon melanocytes have been distinguished from sebocyte-like melanocytes by the shape of the nucleus, which is mostly oval in the former and scalloped in the latter.3 Regardless of this subtle distinction, however, balloon and sebocyte-like melanocytes are always intermingled in the same lesion3 and could be considered a morphologic spectrum. The peculiar ballooning appearance is supposed to be due to progressive vacuolization of melanosomal organelles caused by intrinsic apoptotic processes of the melanocytes.4,5 This apparently does not alter immunohistochemical characteristics of balloon cell melanocytes, being immunoreactive with S100, HMB45, and Melan-A, as usual melanocytes. The ballooning phenomenon does not show a correlation with prognosis, as well. In the largest series of balloon cell melanoma,6 as expected, the prognosis is related to Breslow thickness, and it is not dependent on cytological characteristics. A common feature of balloon cell melanoma is the massive involvement of the dermis with a vertical growth phase or a nodular pattern, being the spread to the epidermis very rare,2,7 and the exclusively intraepidermal (in situ) localization has never been described so far. In the present case, balloon melanocytes show an unequivocal malignant feature, that is, prominent pagetoid ascent in the epidermis, but maintain an exclusively in situ pattern of growth and can be considered the first reported example of balloon cell in situ melanoma." @default.
• W3013737655 created "2020-04-03" @default.
• W3013737655 creator A5060916338 @default.
• W3013737655 creator A5063098368 @default.
• W3013737655 date "2020-03-24" @default.
• W3013737655 modified "2023-09-28" @default.
• W3013737655 title "Balloon Is Exceptional, Balloon In Situ Even More!" @default.
• W3013737655 cites W1973347590 @default.
• W3013737655 cites W1980603630 @default.
• W3013737655 cites W2031586034 @default.
• W3013737655 cites W2113673288 @default.
• W3013737655 cites W2132184434 @default.
• W3013737655 cites W2145915111 @default.
• W3013737655 doi "https://doi.org/10.1097/dad.0000000000001639" @default.
• W3013737655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32217841" @default.
• W3013737655 hasPublicationYear "2020" @default.
• W3013737655 type Work @default.
• W3013737655 sameAs 3013737655 @default.
• W3013737655 citedByCount "0" @default.
• W3013737655 crossrefType "journal-article" @default.
• W3013737655 hasAuthorship W3013737655A5060916338 @default.
• W3013737655 hasAuthorship W3013737655A5063098368 @default.
• W3013737655 hasConcept C105702510 @default.
• W3013737655 hasConcept C139059822 @default.
• W3013737655 hasConcept C142724271 @default.
• W3013737655 hasConcept C164705383 @default.
• W3013737655 hasConcept C204232928 @default.
• W3013737655 hasConcept C2776350330 @default.
• W3013737655 hasConcept C2776458125 @default.
• W3013737655 hasConcept C2777624698 @default.
• W3013737655 hasConcept C2777658100 @default.
• W3013737655 hasConcept C2779769559 @default.
• W3013737655 hasConcept C2781156865 @default.
• W3013737655 hasConcept C43100952 @default.
• W3013737655 hasConcept C502942594 @default.
• W3013737655 hasConcept C71924100 @default.
• W3013737655 hasConcept C86803240 @default.
• W3013737655 hasConceptScore W3013737655C105702510 @default.
• W3013737655 hasConceptScore W3013737655C139059822 @default.
• W3013737655 hasConceptScore W3013737655C142724271 @default.
• W3013737655 hasConceptScore W3013737655C164705383 @default.
• W3013737655 hasConceptScore W3013737655C204232928 @default.
• W3013737655 hasConceptScore W3013737655C2776350330 @default.
• W3013737655 hasConceptScore W3013737655C2776458125 @default.
• W3013737655 hasConceptScore W3013737655C2777624698 @default.
• W3013737655 hasConceptScore W3013737655C2777658100 @default.
• W3013737655 hasConceptScore W3013737655C2779769559 @default.
• W3013737655 hasConceptScore W3013737655C2781156865 @default.
• W3013737655 hasConceptScore W3013737655C43100952 @default.
• W3013737655 hasConceptScore W3013737655C502942594 @default.
• W3013737655 hasConceptScore W3013737655C71924100 @default.
• W3013737655 hasConceptScore W3013737655C86803240 @default.
• W3013737655 hasIssue "10" @default.
• W3013737655 hasLocation W30137376551 @default.
• W3013737655 hasOpenAccess W3013737655 @default.
• W3013737655 hasPrimaryLocation W30137376551 @default.
• W3013737655 hasRelatedWork W2003324866 @default.
• W3013737655 hasRelatedWork W2025683441 @default.
• W3013737655 hasRelatedWork W2072260414 @default.
• W3013737655 hasRelatedWork W2168586854 @default.
• W3013737655 hasRelatedWork W2390190834 @default.
• W3013737655 hasRelatedWork W2409190629 @default.
• W3013737655 hasRelatedWork W2411192782 @default.
• W3013737655 hasRelatedWork W2462526598 @default.
• W3013737655 hasRelatedWork W3007215145 @default.
• W3013737655 hasRelatedWork W2078290468 @default.
• W3013737655 hasVolume "42" @default.
• W3013737655 isParatext "false" @default.
• W3013737655 isRetracted "false" @default.
• W3013737655 magId "3013737655" @default.
• W3013737655 workType "article" @default.